Zhonglin Xie, MD, PhD Assistant Professor of Medicine
Mailing Address: 941 Stanton L. Young Blvd., BSEB 302B Oklahoma City, OK 73104-5020	Telephone: (405) 271-3077 Fax: (405) 271-3973
Email: zxie@ouhsc.edu

Research Interests

1. Molecular mechanism of AMP-activated kinase activation and its role in cardiovascular diseases.

2. Oxidative stress and diabetic cardiomyopathy.

3. Matrix modulation and cardiac remodeling

Education

Xie Z, Dong Y, Scholz R, Neumann D, Zou MH. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation. 117:952-62; 2008.

Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. Protein Kinase C ζ-dependent LKB1 serine 428 phosphorylation increases lkb1 nucleus export and apoptosis in endothelial cells . J Biol Chem. 2008 Mar 5; [Epub ahead of print] PMID: 18321849.

Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, Zou MH.Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res. 102:328-37; 2007.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation. 116:1585-95; 2007.

Xie Z., Davis B., Zhang M., Cui M.Z., Riek U., Neumann D., Shi C., Hou X., Cohen R., Zou M.H. Activation of Protein Kinase-C By Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase In Endothelial cells. J. Biol Chem. 281:6366-75, 2006.

Xu, J., Xie, Z., Reece, R., Pimental, D., Zou, M.H.  Hypochlorous acid uncouples endothelial nitric oxide synthase:  Role of vascular NAD(P)H oxidase-derived superoxide and peroxynitrite. Atherosclerosis, Thrombosis, and Vascular Biology. 26:2688-2695:2006.

Davis B., Xie Z., Wiles IV, W. G., Viollet B., Zou M.H. Activation of the AMP-activated Kinase By Anti-diabetic Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo By Promoting The Association Of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase. Diabetes 55:496-505; 2006.

Xu J, Xie Z, Reece R, Zou MH. Hypochlorite Activates Vascular NADP(H) Oxidase and Uncouples Endothelial Nitrite Oxide Synthase: Role of Reactive Nitrogen Species.  Circulation 112:II-141; 2005.