Jian Xu, PhD
Assistant Professor of Research |
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Mailing Address:
941 Stanton L. Young Blvd., BSEB 315
Oklahoma City, OK 73104 |
Telephone:
(405) 271-5896 ext 48496
Fax:
(405) 271-3973 |
| Email: jian-xu@ouhsc.edu |
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Research Interests
- Mechanisms of oxidative and/or nitrosative stresses on cardiovascular diseases.
- Host defense and endothelial activation: role of innate immunity; interactions of leukocyte with endothelium in cardiovascular disorders.
- UPS (ubiquitin-proteasome-system) in diabetes and its complications.
Education
| 2002 |
PhD - Biochemical Pharmacology, University of Konstanz, Konstanz, Germany |
| 1988 |
MS - Biochemistry, Xinjiang Agricultural University, Urumqi, China |
| 1985 |
BS - Biology, Shaanxi Normal University, Xi'an, China |
Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation. 2009; (in press).
Xu J, Wang S, Wu Y, Song P, Zou MH. Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. Hypertension. 2009; (in press).
Wang S, Xu J, Song P, Viollet B, Zou MH. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I Diabetes. 2009; Jun 15. (Epub of print).
Song P, Zhang M, Wang S, Xu J, Choi HC, Zou MH. Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem. 2009;284:17120-17128.
Wang SX, Xu J, Song P, Wu Y, Zou MH. Acute Inhibition of GTP Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Systolic Blood Pressure. Hypertension. 2008, 52(3):484-90.
Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons T, Zou MH. Activation of Protease Calpain by Oxidized and Glycated LDL Increases the Degradation of Endothelial Nitric Oxide Synthase.J Cell Mol Med. 2008 Jun 28. [Epub ahead of print]
Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH. Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statin in Vivo. J Biol Chem. 2008 Jul 18;283(29):20186-97.
Song, P., Xie, Z., Wu, Y., Xu J, Dong, Y. and Zou, MH. Protein kinase C zeta -dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem. 2008; 283(18):12446-55.
Zhang, M., Dong, Y., Xu J, Xie, Z., Wu, Y., Song, P., Guzman, M., and Zou, MH. Thromboxane receptor via hydrogen peroxide activates the AMP-activated kinase in vascular smooth muscle cells. Circulation Research 2008; 102(3):328-37.
Wenzel, P., Daiber, A., Oelze, M., Brandt, M., Closs, E., Xu J, Thum, T., Bauersachs, J., Ertl, G., Zou, MH., Förstermann, U. and Münzel, T. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis. 2008; 198(1):65-76.
Song, P., Wu, Y., Xu J, Xie, Z., Dong, Y., Zhang, M. and Zou, MH. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN in an LKB1-dependent manner. Circulation. 2007; 116 (14): 1585-95.
Xu J, Wu, Y., Song, P., Zhang, M., Wang, SX. and Zou MH. Proteasome-dependent degradation of guanosine 5-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation. 2007; 116 (8): 944-53.
Wu, Y., Song, P., Xu J, Zhang, M. and Zou, MH. Activation of protein phosphoatase PP2A by palmitic acid inhibits the AMP-activated protein kinase (AMPK). Journal of Biological Chemistry. 30; 282(13):9777-9788, 2007.
Xu J., Xie, Z., Reece, R., David Pimental and Ming-Hui Zou. Uncoupling of endothelial nitric oxide synthase by Hypochlorous acid. Role of vascular NAD(P)H oxidase-derived superoxide and peroxynitrite. Arteriosclerosis, Thrombosis, and Vascular Biology. 26(12):2688-2695, 2006.
*Comment in (Editorial): Rabelink, TJ and von Zonneveld, AJ: Coupling eNOS uncoupling to the innate immune response. Arteriosclerosis, Thrombosis, and Vascular Biology. 26(12):2585-2587, 2006.
Nie, H., Wu, JL., Zhang, M., Xu, J. and Zou, MH. Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes mellitus in vivo. Diabetes. 55(11):3133-3141, 2006.
Abstracts
Xu, J. and Zou, M.H. Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. The 3rd OPTM: Oxidative Post-Translational Modifications in the Cardiovascular System. Boston, MA. October 1-3, 2008.
Xu, J., Wang, SX., Wu, Y., Song, P. and Zou, M.H. Oxidative Stress Induces Endothelial Dysfunction: Role Ubiquitin-Proteasome System. 2007 Scientific Sessions of AHA, Orlando, Florida: November 4-7, 2007.
Xu. J. and Zou, MH. Hyperglycemia-induced endothelial dysfunction is mediated by the proteasome-dependent degradation of GTP-cyclohydrolase I. Diabetes. 66th Scientific Sessions of ADA, Volume 55 Supplement 1, June 2006, Cellular Mechanism in CVD (Cardio-Vascular Diseases): 139-OR, A33 (Oral presentation).
Xu, J., Xie, Z., Reece, R. and Zou, M.H. Hypochlorite activates vascular NAD(P)H oxidase and uncouples endothelial nitric oxide synthase: Role of reactive nitrogen species. Circulation. 2005 Scientific Sessions of AHA, Volume 112, Number 17, October 25, 2005; Endothelial roles in atherosclerosis. II-141-142 (Oral presentation).
Xu, J., Xie Z., Nelson, J., Kirkpatrick, S., Zou, M.H. Hypochlorite-induced vascular endothelial dysfunction. The 6th Annual Conference on Arterosclerosis, Thrombosis, and Vascular Biology, the Grand Hyatt Washington, Washington, DC, April 28 to 30, 2005.
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