Alicia Jenkins, MD, FRACP Professor
Mailing Address: 941 Stanton L. Young Blvd., BSEB 302F Oklahoma City, OK 73104	Telephone: (405) 271-5896 ext.46377 Fax: (405) 271-3973
Email: alicia-jenkins@ouhsc.edu

Research Interests

1. Mechanisms of the vascular complications of diabetes. Lipids in diabetes. Role of inflammation, oxidative stress, and dyslipidemia in complications of diabetes. Mentorship of laboratory and clinical scientists.

Clinical Interests

1. Management of diabetes in youth and adolescence.

EDUCATION:

Davis TME, Ting R, Best JD, Donoghoe M, Drury PL, Sullivan D, Jenkins AJ, O’ Connell R, Glasziou P, Simes RJ, Kesaniemi YA, Gebski V, Scott R, Keech AC, on behalf of the FIELD study. (2010). Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus (FIELD Study): a pre-specified analysis of a randomised controlled trial.  Diabetologia. In press Sept. 2010.

Jenkins AJ, Krishnamurthy B, Colman P, Rodda C, Cameron F, O’Connell M, Teede H, Hamblin S, Best JD, and O’Neal D. (2010).  An Algorithm Guiding Responses to Real-Time Continuous Glucose Monitoring Improves Quality of Life. Diabetes Technologies and Therapeutics In press Sept.  2010. 

Beauchamp A, Tonkin A, Peeters A, Wolfe R, Turrell G, Harriss L, Otvos JD, Giles GG, English DR, and Jenkins AJ. (2010). Smoking status, lifestyle and lipoprotein subclasses. J Clin Lipidology In press Sept. 2010.

Sasongko MB, Wong TY, Nguyen TT, Kawasaki R, Jenkins AJ, Shaw J, and Wang JJ. (2010). Serum Apolipoprotein AI and B are Stronger Predictors of Diabetic Retinopathy than Traditional Lipids.  Diabetes Care. In press Sept. 2010.

Rasmussen B, Ward G, Jenkins AJ, King SJ, and Dunning P. (2010). How young adults with Type 1 diabetes manage life transitions. Journal of Clinical Nursing.  In Press July 2010

Brown BE, Nobecourt E, Zeng J, Jenkins AJ, Rye KA, and Davies MJ. (2010).  Late but not early glycation of ApoA1 impairs cholesterol efflux from lipid-laden macrophages. Atheroslcerosis  In press 2010.      

Jenkins AJ, McBride J, Januszewski AS, Karschimkus C, Zhang B, Nelson CL, O’Neal D, Chung JS, Harper CA, Lyons TJ, and Ma JX. (2010).  Increased serum kallistatin in Type 1 diabetes and its complications.  J. Angiogenesis Research.  In press June 2010.

Klein RL, Carter RE, Jenkins AJ, Lyons TJ, Baker NL, Gilbert GE, Virella G, Lopes-Virella M, DCCT Research Group. (2010).  LDL-containing Immune Complexes in the DCCT-EDIC cohort: Associations with Lipoprotein Subclasses.  J Diabetes and its Complications. In press May 2010.

Chan DC, Hamilton SJ, Rye KA, Chew GT, Jenkins AJ, Lambert G, and Watts GF. (2010). Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients. Diabetes Obes Metab. 2010;12(9):752-6.

Sasongko MB, Wang J, Donaghue KC, Cheung N, Benitez-Aguirre P, Jenkins A, Hsu W, Lee M-L, and Wong TY. (2010). Alterations in Retinal Microvascular Geometry in Young Type 1 Diabetes.  Diabetes Care  2010; 33(6):1331-1336.

Jenkins AJ, Krishnamurthy B, Colman P, Rodda C, Cameron F, O’Connell M, Teede H, Hamblin S, Best JD, and O’Neal D. (2010).  Evaluation of an Algorithm to Guide Patients with Type I Diabetes Treated with Continuous Subcutaneous Insulin Infusion (CSII) on How to Respond to Real-Time Continuous Glucose Levels- A Randomised Control Trial. The ALGOS Study. Diabetes Care 2010; 33(6):1242-1248

Nobecourt E, Tabet F, Lambert G, Puranik R, Bao S, Yan L, Davies MJ, Brown BE, Jenkins AJ, Dusting GJ, Bonnet DJ, Curtiss LK, Barter PJ, and Rye K-R. (2010).  Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I. Atherosclerosis, Thrombosis and Vascular Biology. 2010; 30(4)766-772

Griffin M, Wilson A, Mok YF, Januszewski AS, Wilson AM, Karschimkus C, Romas E, Lee AB, Godfrey T, Wong M, Clemens L, Jenkins AJ, and Howlett G. (2010). Thioflavin T fluorescence in human serum: Correlations with vascular health and cardiovascular risk factors. Clinical Biochemistry  2010; 43(3):278-286.

Campbell DJ, Kladis A, Zhang Y, Jenkins AJ, Yii M, Kenny JF, and Kelly DJ. (2010).  Increased tissue kallikrein expression in type 2 diabetes.  Diabetologia  2010; 53(4):779-785.

Brazionis L, Yau J, Itsiopoulos C, O’Dea K, Wong T, and Jenkins AJ. (2010). PAI-1 activity and retinal vascular calibre in type 2 diabetes.  Diab Res Clin Prac. 2010;87(2):192-199

Lim SW, Cheung N, Wang JJ, Donaghue K, Liew G, Islam FM, Jenkins AJ, and Wong T. (2009). Retinal Vascular Fractal Dimension and Risk of Early Diabetic Retinopathy: A Prospective Study of Children and Adolescents with Type 1 Diabetes. Diabetes Care 2009; 32(11):2081-2083.

Vethakkan SR, Jenkins AJ, Kay TWH, Goodman DJ, Walters JM, Gooley JL, Boston RC, Holmes-Walker DJ, and Ward GM. (2009). Improved 2nd phase insulin secretion and preserved insulin sensitivity following islet transplantation. Transplantation In press: accepted Dec, 2009

Hodge A, Jenkins AJ, Tonkin AM, O’Dea K, and Giles G. (2009). NMR determined plasma lipoprotein profile is associated with dietary composition and body size.  Nutrition, Metabolism & Cardiovascular Diseases. In press Dec 2009.

Cheung NW, Conn JD, d'Emben JC, Gunton JE, Jenkins AJ, Ross GP, Singha AK, Adrikopoulos S, Colagouri S, and Twigg SM. (2010). Position Statement of the Australian Diabetes Society: individualisation of glycated haemoglobin tares for adults with diabetes mellitus. Medical Jounrnal of Australia. 2009 191(6):339-344.

Luke J, Brown A, O’Neal D, O’Dea K, Jenkins AJ, Kelaher M, Best J, and Rowley K. (2009).  Lipid treatment guidelines and cardiovascular risk for Aboriginal people in Central Australia.  Medical Journal of Australia.  2009; 190(10):552-556.

Chen S, Jenkins AJ, and H Margolius. (2009).  Elevated prostaglandins and monocyte acetylated histone in Type 1 diabetes patients.  Diabetic Medicine 26(2):182-186.

ADS Council. HbA1c guidelines in Diabetes. (2009). Medical Journal of Australia. In press July 2009. 

Kreis AJ, Wang JJ, Islam FMA, Klein R, Klein BEL, Cotch MF, Sharrett AR, Jenkins AJ, Shea S, and Wong TY. (2009).  Nuclear Magnetic Resonance Lipoprotein Subclass and Diabetic Retinopathy: The Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes and Vascular Disease Research 6(1):40-42.

Yu Y, Jenkins AJ, Nankervis AJ, Hanssen K, Scholz H, Henriksen T, Lorentzen B, Garg SK,  Menard MK, Hammad S, Scardo JC, Stanley JR, Dashti A, May K, Lu K, Aston CE, Zhang SX, Ma J-x, and Lyons TJ. (2009). Anti-angiogenic factors and preeclampsia in Type 1 diabetes. Diabetologia  52:160-168.

Shemesh T, Rowley K, Jenkins AJ, Best JD, and O'Dea K. (2009). C-reactive protein levels are very high and more stable over time than the traditional vascular risk factors total cholesterol and systolic blood pressure in an Australian Aboriginal cohort.  Clinical Chemistry 55(2):336-341.

Hodge A, Jenkins A, English D, O’Dea K, and Giles GG. (2009). NMR-determined lipoprotein subclass profile predicts Type 2 diabetes.  Diabetes Research and Clinical Practice. 83(1):132-139.

Valaydon ZS, Lee P, Dale GL, Januszewski AS, Rowley KG, Nandukar H, Best JD, Lyons TJ, and Jenkins AJ. (2009).  Increased Coated-Platelet Levels in End Stage Renal Disease Patients. Nephrology   14(2):148-154.

Cheung N, Donaghue KC, Liew G, Wang JJ, Lim SW, Jenkins AJ, Hsu W, Lee ML, and Wong TY.  (2009). Fractal Dimension of the Retinal Vascular Network and Retinopathy in Type 1 Diabetes.  Diabetes Care 32(1):106-110.

Rowley K, Anderson I, McDermott R, Tilmouth R, Roberts I, Joseph F, Wang Z, Jenkins A, Best D, Brown A, and O’Dea K. (2008).Lower than expected morbidity and mortality for an Australian Aboriginal population: 10 year follow up in a decentralised community.  Medical J. Australia 188(5):283-7.

Januszewski AS, Thomas MC, Chung SJ, Karschimkus CS, Rowley KG, Nelson C, O'Neal D, Wang Z, Best JD, and Jenkins AJ. (2008).  Longitudinal study of LMW-AGEs in Type 1 diabetes. In press J Med Invest Jan.

Brock J, Jenkins AJ, Lyons TJ, Klein RL, Yim E, Lopes-Virella M, Carter RE, DCCT/EDIC Research Group, Thorpe SR, and Baynes JW. (2008).   Increased Methionine Sulfoxide Content of ApoA1 in Type 1 Diabetes.  J Lipid Res. 49(4):847-55. 

Brazionis L, Rowley K, C Itsiopoulos, Jenkins AJ, and O’Dea K. (2008).  PAI-1 relationship with CHD and retinopathy is divergent.  Atherosclerosis, Thrombosis and Vascular Biology. 28(4):786-91. 

Hoffmann P, Woon J, Rowley KG, Karshimkus C, Nelson CL, Dragicevic G, O'Neal D,  Wilson A, Croft K, Mori T, Kemp BE, Best JD, and Jenkins AJ. (2008).   Glutathionyl hemoglobin is not increased in diabetes nor related to glycaemia or vascular complications.  Diabetes Research and Clinical Practice.  80(2):e1-3.

O'Neal DN, Piers LS, Iser DM, Rowley KG, Jenkins AJ, Best JD, and O'Dea K. (2008).  Australian Aboriginal People and Torres Strait Islanders have an atherogenic lipid profile that is characterised by low HDL-cholesterol level and small LDL particles.  Atherosclerosis In press March 2008.

Yau J, Lee P, Wong T, Best JD, and Jenkins AJ. (2008).  Cardiovascular and Thrombophilic
Risk Factors Associated with Retinal Vein Occlusion.  Internal Medicine Journal. In press March 2008.

Jenkins AJ*, Rothen M*, Klein RL, Moller K, Eldridge L, Zheng D, Durazo-Arvizu R, McGee D, Lackland D, Thorpe SR, Garvey WT, Lyons TJ; the DCCT/EDIC Research Group. (2008).   * equal first author.  Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort. J Diabetes Complications. 2008;22(3):153-163. Epub Apr 16.

Jenkins AJ*, Gosmanova A*, Lyons TJ, May K, Dashti A, Baker MZ, Olansky L, Aston CE, and Dale GL.  (2008). Coated-Platelet Levels in Type 1 and Type 2 Diabetes Mellitus.  * equal first author.  Diabetes Res and Clin Prac. In press April 2008

Gallego P, Craig M, Duffin, A, Bennetts,  B, Jenkins AJ, Hofer S, Lam A, and Donaghue K. (2008).  Association between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects with Type 1 Diabetes.  Diabetes Care 2008 May 9. [Epub ahead of print]

Valaydon ZS, Lee P, Dale GL, Januszewski AS, Rowley KG, Nandukar H, Best JD, Lyons TJ, and Alicia J Jenkins. (2008).  Increased Coated-Platelet Levels in End Stage Renal Disease Patients. In revision Nephrology  April.

Brown BE, Nobecourt E, Zeng J, Jenkins AJ, Rye KA, and Davies MJ. (2008).  Late but not early glycation of ApoA1 impairs cholesterol efflux from lipid-laden macrophages. In revision Diabetologia May.   

Wilson AM, Swan JD, Ding H, Zhang Y, Whitbourn RJ, Gurry J, Yii M, WilsonAC, Hill M, Triggle C, Best JD, and Jenkins AJ. (2007). Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy.  Atherosclerosis. 191(1):175-81.

Shemesh T, Rowley KG, Jenkins A, Brimblecombe J, Best JD, and O'Dea K. (2007).  Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia.  Int J Obes (Lond). 31(3):564.

Lopes-Virella MF, McHenry MB, Lipsitz S, Yim E, Wilson PF, Lackland DT, Lyons T, Jenkins AJ, Virella G; The DCCT/EDIC Research Group. (2007). Immune complexes containing modified lipoproteins are related to the progression of internal carotid intima-media thickness in patients with type 1 diabetes.  Atherosclerosis 190(2):359-69.

Choo KE, Lau KB, Davis WA, Chew PH, Jenkins AJ, and Davis TM. (2007).  Effects of diabetic parentage on cardiovascular risk factors in pre-pubertal Malay children.  Diabetes Research and Clinical Practice 76(1):119-125

Nobecourt E, Davies MJ, Brown BE, Curtiss LK, Bonnet DJ, Charlton F, Januszewski AS, Jenkins AJ,  Barter PJ, and Rye K-A. (2007).  The Impact of Glycation on Apolipoprotein A-I Structure and its Ability to Activate Lecithin:Cholesterol Acyltransferase Diabetologia. 50(3):643-53.

Campbell DJ, Woodward M, Chalmers JO, Colman SA, Jenkins AJ, Kemp BE, and Neal BC. (2007).  Low Density Lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease.  Eur. J. of Cardiovascular Prevention and Rehabilitation.  14(3):413-8.

Pham T, Cornea A, Blick KE, Jenkins AJ, and Scofield RH. (2007). Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance.  Am J Med Sci 333(6):333-9.

McLachlan K, Jenkins A, and O’Neal D. (2007). The Role of Continuous Glucose Monitoring in Clinical Decision Making in Diabetes.  ANZ J Ob and Gynae.  47(3):186-90.

Jenkins AJ*, Zhang SX*, Rowley KG, Karschimkus CS, Nelson C, Chung SJ, O'Neal D, Harper CA, Januszewski AS, Croft KD, Mori TA, Lyons TJ, Best JD, and Ma JX. (2007).  Increased Serum PEDF is Associated With Microvascular Complications, Vascular Stiffness, and Inflammation in Type 1 Diabetes.  * equal 1st author Diabetic Medicine 24(12):1345-51. 

Yu Y, Li W, Wojciechowski B, Jenkins AJ, and Lyons TJ. (2007).  Effects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar Aminoguanidine.  American Journal of Pharmacology and Toxicology.  In press 2007.

Campbell DJ, Woodward M, Chalmers JP, Colman SA, Jenkins AJ, Kemp BE, Neal BC, Patel A, and MacMahon SW. (2006). Soluble vascular cell adhesion molecule 1 and N-terminal pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease. Arch Neurol. 63(1):60-5.

Lee A, Godfrey T, Rowley K, Karschimkus C, Dragicevic G, Romas E, Clemens L, Wilson A, Nikpour M, Prior D, Best J, and Jenkins A. (2006). Adverse risk factor profile in stable mild SLE.  Int Med 36(4):237-243.
 
Mason NJ, Jenkins AJ, Best JD, and Rowley KG. (2006).  Exercise frequency and arterial compliance in non-diabetic and Type 1 diabetic subjects.  Eur J Cardiovasc Prev Rehabil. 13(4):598-603.

Wilson LM, James PF, Jenkins AJ, Wade JD, Hill AF, Perugini MA, and Howlett GJ. (2006).  High density lipoproteins bind Abeta and apolipoprotein C-II amyloid fibrils.   J. of Lipid Research 47(4):755-60.

Alibrahim E, Donaghue KC, Rogers S, Hing S, Jenkins AJ, Chan A, and Wong TY. (2006).  Retinal Vascular Caliber and Risk of Retinopathy in Type 1 Diabetes Mellitus.  Ophthalmology. 113(9):1499-503.

Hofer SE, Bennetts B, Chan AK, Holloway B, Karschimkus C, Jenkins AJ, Silink M, and Donaghue KC. (2006). Association between PON 1 polymorphisms, PON activity and diabetes complications. J Diabetes Complications. 20(5):322-8.

Yu J, Thorpe SR, Jenkins AJ, Shaw JN, Sochaski MA, McGee D, Aston CE, Orchard TJ, Silvers N, Peng YG, McKnight AJ, Baynes JW, Lyons TJ, The DCCT/EDIC Research Group. (2006). Advanced Glycoxidation End-Products and Methionine Sulfoxide in Skin Collagen in Type 1 Diabetes.  Diabetologia 49(10):2488-98.

Lyons TJ, Jenkins AJ, Zheng D, Klein RL, Otvos JD, Yu Y, Lackland DT, McGee D, McHenry MB, Lopes-Virella M, Garvey WT; DCCT/EDIC Research Group. (2006). Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness. Diabet Med. 23(9):955-66.

McLachlan KA, O'Neal D, Jenkins A, and Alford FP. (2006). Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy.  Diabetes Metab Res Rev. 22(2):131-8.

Book Chapters

Jenkins AJ, de Dios S, and Januszewski AS. (2009). Diabetes Mellitus and Oxidative Stress.  In Cardiovascular Disease and Oxidative Stress.  Novapublishers In press 2009. 

Jenkins AJ, Hill MA, Rowley K.  Diabetes and Oxidant Stress. In: Atherosclerosis and Oxidant Stress.  Ed. Holtzman J.  In press 2007. (Launced American Heart Association Meeting)

Polya GM, Polya Z and Jenkins AJ. Plant natural products and diabetes - biochemical pharmacology and prospects. In Recent Progress in Medicinal Plants, Vol. II, Phytochemistry and Pharmacology (S. Singh, V.K. Singh and J.N. Govil, eds.), Research Periodicals & Book Publishing House, Houston, TX, USA.  2003.

Professional Journal Articles

Jenkins A, and O’Neal D. (2010).  The Legacy Effect in Type 2 Diabetes. Diabetes Management 2010 In press.

O’Neal D, and Jenkins A. (2010).  Real-time glucose monitoring.  InfuSystems Asia 2010. In press.

Jenkins AJ, Kilmartin G, Kilmartin J, Bora S, and O’Neal, DN. (2009).  Upskilling Health Care Professionals in CSII.  InfuSystems In press 2009. 

O’Neal D, and Jenkins A. (2009). Real-time glucose monitoring – its time has almost arrived?  Diabetes Management 2009 Vp;I,e 28, p4-5.

Jenkins A, and O’Neal D. (2009). Metabolic Memory in Type 1 Diabetes. Diabetes Management June.

Jenkins AJ, and O’Neal D. (2007). Hypoglycaemia Awareness.  Diabetes Management. 

O’Neal D, and Jenkins AJ.  (2006). Insulin pump therapy in Type 1 diabetes: A brief review of the evidence. Infusystems Asia.  Vol 1. No 3.

Jenkins AJ. (2006). Diabetes Care in the Future.  NovoNews August.

Jenkins AJ.  (2006). Diabetes complications and genes.  Diabetes Management.

O’Neal D, and Jenkins AJ. (2006). Continuous glucose monitoring.  Diabetes Management.

Jenkins AJ, and O’Neal D. (2006). Diabetic dyslipidaemia.  Diabetes Management. 

Invited Reviews

Ford PJ, Raphael SL, Cullinan MP, Jenkins AJ, West MJ, and Seymour GJ. (2010). Why should a doctor be interested in oral disease?  Expert Reviews Cardiology.  In press July 2010.

Yau J, Lee P, Wilson A, and Jenkins AJ.  (2010). Metal Prosthetic Valve Endocarditis.  Evidence for anticoagulation.  Internal Medicine Journal. In press June 2010.

Yau J, Lee P, Wong T, Best JD, and Jenkins AJ. (2010). Cardiovascular and Thrombophilic
Risk Factors Associated with Retinal Vein Occlusion.  Internal Medicine Journal. 2008;38(12):904-910.

Bennett CM, Jenkins AJ, Guo M, and Dharmage SC. (2007). Will global standardizsation of test reporting make HbA1c the preferred diabetes screening test?  Endocrine Reviews  In press 2007.

Andrews KL, Pannirselvam M, Anderson TJ, Jenkins AJ, Triggle CR, and Hill MA. (2005).  The vascular endothelium in diabetes: A practical target for drug treatment? Expert Opinions in Theraputic Targets.  9(1):101-17.

Dudley AC, Thomas D, Best J, and Jenkins A. (2004).   The STATS in cell stress-type responses.  Cell Commun  Signal. 6;2(1):8.

Jenkins AJ, Garvey WT, and Klein RL. (2004).  Lipoproteins in Type 1 Diabetes.  Current Opinion in Endocrinology and Diabetes.

Jenkins A, Klein R, Lyons T, and Best J. (2004).  Glycoxidation, Lipoproteins and Diabetic Angiopathy.   Diabetes Metab Res Rev.  20(5):349-68.

Jenkins AJ, Rowley K, Lyons TJ, Hill MJ, Best JD, and Klein RL. (2004). Lipoproteins and diabetic microvascular complications. Curr Pharm Design. 10, 3395-3418.

Invited Lectures

Diabetes, the damage that it does. Australian Sonographers Association Conference.  Plenary Lecture. Melbourne, May 2010.

Insulin pumps.  DA Vic Insulin Pump Expo, Melbourne, March 2010.

Insulin pumps and real time glucose sensors. World Internal Medicine Conference, Melbourne, March 2010.

Lipoproteins and adiposity in Type 1 diabetes.  International Society Paediatric and Adolescent Diabetes (SPAD) Annual Conference, Lubijana, Slovenia, Sept. 2009.

The ALGOS Study: Effects of CSII RT-CGM on glycaemia in Type 1 diabetes.  Oral Presentation ADA New Orleans, June 2009.

NMR dyslipoproteinaemia and gender and the effects of fenofibrate in the FIELD Study.  Oral Presentation. ADS Meeting, Adelaide, August 2009.

The Science Behind Insulin Pumps.  Australian Diabetes Society Annual Scientific Meeting, Adelaide, August 2009.

Teleopthalmology and Telemedicine Potential for Health Care of Indigenous Australians.  Melbourne, April 2009.