James T. Lane, MD Professor of Medicine Director of Adult Clinical Programs Harold Hamm Chair in Clinical Diabetes Research
Mailing Address: 1000 N. Lincoln Blvd., HHDC 2900 Oklahoma City, OK 73104-3252	Telephone: (405) 271-5896 Fax: (405) 271-7522
Email: james-lane@ouhsc.edu

Research Interests

My background is in clinical research involving people with both type 1 and type 2 diabetes.  I have worked a great deal in the area of end-organ complications of diabetes, as it relates to the kidney, eyes, nerves, and the cardiovascular system.  For patients who have developed diabetes, the avoidance of complications remains a prominent target and one I plan to continue to pursuit.  One way of avoiding complications is to maintain good glucose control.  In addition, other treatments that may be organ-specific and not directly targeted at glucose control, may prevent or slow the progression of end-organ complications.

I have also had a background in two specific areas of diabetes.  They include the treatment of young adults with diabetes and new-onset diabetes after transplantation.  I have developed a young adult diabetes clinic that addresses the care of young adults with diabetes.  This age group is associated with special challenges and is also associated with blood sugar control that is less than what we promote for our adults with diabetes.  How we treat young adults goes beyond blood sugar control and addresses personal concerns, methods of learning and the development of autonomous self-care, and how young adults make the transition to a healthy adult.  Our goal is to develop such a clinic at the Harold Hamm Oklahoma Diabetes Center with colleagues from Pediatric Endocrinology.  The other area of specialty is in the care of transplant patients who develop diabetes after solid organ transplantation.  This is a major problem in patients who have transplants for kidney, liver, and heart.

Administrative role
I look forward to working with my colleagues at the Harold Hamm Diabetes Center in developing a world-recognized clinical diabetes center where patients can come for excellent care.  This includes working with professionals from a variety of disciplines, such as physicians, mental health professionals, nurses, dieticians, and administrative professionals. 

With diabetes affecting up to 10% of people in Oklahoma, I look forward to working with our staff and those in our community about ways to potentially prevent diabetes.  For those who don’t know if they have diabetes, it is important to have access to care and appropriate screening so that they might receive appropriate medical care. 

Education

Lane JT,  Odegaard DE, Haire CE, Collier DS, Wrenshall LE, Stevens RB.  Short-term sitagliptin therapy in recipients of a kidney transplant with new onset diabetes after transplantation.  Submitted to Diabetes, Obesity and Metabolism.  January 2011.

Lane JT.  Animal model of human maturity onset diabetes of the young—Type 2: similar but different (Editorial).  Translational Research 157: 109-110, 2011.

Colvin, R.J., and Lane, JT.  Your Guide to Type 2 Diabetes.  Your Health Companion Books Inc., Omaha, NE 2011.

Stevens RB, Lane JT, Boerner BP, Miles CD, Rigley TH, Sandoz JP, Nielsen KJ, Skorupa JY, Skorupa AJ, Kaplan B, Wrenshall LE. Single-dose rATG at renal transplantation; superior renal function and glucoregulation with less hypomagnesemia indicate reduced tubular injury.  In Press. Clinical Transplantation.

Lancaster BM, Pfeffer B, McElligott M, Ferguson AT, Miller M, Wallace D, Lane JT.  Assessing treatment barriers in young adults with Type 1 diabetes.  Diabetes Research and Clinical Practice 90: 243-249.

Lane JT, Larson L, Fan S, Stoner JA, Margalit E, Toris CB.  Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications. BMC Ophthalmology 10: 19, 2010.

Lane, JT, Shivaswamy, V, and Larsen, J.  Term Metabolic and other Consequences Pancreas and Islet Transplantation. Book Chapter In: Pancreas, Islets and Stem cell transplantation for the treatment of diabetes (second edition). Oxford Press. In press, February 2009.

Stevens RB, Mercer DF, Grant WJ, Freifeld AG, Lane JT, Groggel GC, Rigley TH, Nielsen KJ, Henning ME, Skorupa JY, Skorupa AJ, Christensen KA, Sandoz JP, Kellogg AM, Langnas, Wrenshall LE.  Randomized trial of single-dose vs. divided dose rabbit anti-thymocyte globulin induction in renal transplantation: an interim report. Transplantation.  85:1391-1399, 2008. 

Giglio P, Lane JT, Barkoukis TJ, Dumitru I.  Sleep Physiology, in Barkoukis TJ and Avidan AY (eds): Review of Sleep Medicine, Second Edition. Philadelphia: Butterworth Heinemann Elsevier, 2007, pp 29-42. 

Lane JT, Ferguson A, Hall J, McElligott M, Miller M, Lane PH, Pfeffer E.  Glycemic control over 3 years in a young adult clinic for patients with type 1 diabetes.  Diabetes Research and Clinical Practice. 78:385-391, 2007.

Toris CB, Lane JT, Akagi Y, Blessing K, Kador PF.  Aqueous flow in galactose-fed dogs.   Exp Eye Res. 83:865-70, 2006.

Sulanc E, Lane JT, Puumala S, Groggel G, Wrenshall L, Stevens R.  New-onset diabetes after kidney transplantation: an application of 2003 International Guidelines.  Transplantation.  80:945-952. 2005.  

Lane JT, Mack-Shipman L, Anderson J, Moore T, Erickson J, Ford T, Stoner J, Larsen J.  A comparison of computed tomography and dual-energy x-ray absorptiometry using a modified trunk compartment for the measurement of abdominal fat. Endocrine.  27:293-298, 2005. 

Colling C, Stevens R, Lyden E, Lane JT, Mack-Shipman L, Wrenshall L, Larsen J.  Greater early pancreas graft loss in women compared to men after simultaneous pancreas-kidney transplantation.  Clinical Transplantation.  19:158-161, 2005.  

Wei P, Lane PH, Lane JT, Padanilam BJ, Sansom SC.  Glomerular structural and functional changes in a high-fat diet mouse model of early-stage type 2 diabetes.  Diabetologia.  47:1541-1549, 2004. 

Larsen J, Ford T, Lyden E, Colling C, Mack-Shipman L, Lane JT.  What is hypoglycemia in well controlled subcutaneous insulin pump-treated type 1 diabetes patients using Continuous Glucose Monitoring System (CGMSâ)?  Endocrine Practice.  10:324-329,  2004. 

Mack-Shipman LR, O’Grady DM, Erickson JM, Walker CW, Moore TE, Burkman T, Lane JT, Larsen, JL.  Heel ultrasonography is not a good screening tool for bone loss in kidney and kidney-pancreas transplant recipients. Clinical Transplantation. 18:613-618,   2004. 

Larsen J, Ratanasuwan T, Burkman T, Colling C, Lynch T,  Erickson J, Lyden E,  Miller S, Lane JT, Mack-Shipman L. Pancreas transplantation improves vascular disease in patients with type 1 diabetes.  Diabetes Care  27:1706-1711, 2004.  

Lane JT.  Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective.  Am J Physiol: Renal Physiology (Invited Review) 286:F442-F450, 2004. 

Lane JT, Ford TC, Larson LR, Chambers WA, Lane PH.  Acute effects of different intensities of exercise in normoalbuminuric/normotensive patients with type 1 diabetes mellitus.  Diabetes Care  27:28-32, 2004. 

Balakrishnan S, Colling C, Burkman T, Erickson J, Lyden E, Maheshwari H, Mack-Shipman L, Lane JT, Larsen J.  Apo E gene polymorphism alters lipids before pancreas transplantation.  Transplantation   74:974-977, 2002.  

Larsen JL, Lane JT, Mack-Shipman L.  Pancreas and Kidney Transplantation.  Current Diabetes Reports   2:359-364, 2002. 

Larsen JL, Ratanasuwan T, Burkman T, Lynch T, Erickson J, Colling C, Lane JT, Mack-Shipman L, Lyden E, Loseke M, Miller S, Leone J.  Carotid intima thickness decreases following pancreas transplantation.  Transplantation  73:936-940, 2002. 

Lane JT, Nakhle SN, Chacko DM, Wang Y-L, Yablonski ME, and Toris CB.  Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes.  Am J Ophthalmol  132:321-327, 2001.  

Lane JT, Ratanasuwan T, Mack-Shipman L, Taylor R, Leone J, Stratta RJ, Miller S, Lyden E, Baker T, and Larsen J:  Cyclosporine challenge test (CCT) revisited:  Does it predict outcome? Clin Transpl  15:28-31, 2001.

Larsen J and Lane JT:  Hyperlipidemia.  Six steps to choosing the right agent.  Advance For Physician Assistants  7:34-39, 1999.

Gannon MC, Nuttall FQ, Lane JT, Fang S, Gupta V, and Sandhofer CR: Effect of 24 hours of starvation on plasma glucose and insulin concentrations in subjects with untreated non-insulin-dependent diabetes mellitus. Metabolism  45:492-497, 1996.

Bagdade JD, Lane JT, Subbaiah PV, Otto ME, Ritter MC:  Accelerated cholesteryl ester transfer in noninsulin-dependent diabetes mellitus.  Atherosclerosis  104:69-77, 1993.

Ercan N, Nuttall FQ, Gannon MC, Lane JT, Burmeister LA, and Westphal SA:  Plasma glucose and insulin responses to bananas of varying ripeness in persons with noninsulin-dependent diabetes mellitus.  J Am Coll Nutr  12:703-709, 1993.

Gannon MC, Nuttal FQ, Lane JT, and Burmeister LA:  Metabolic response to cottage cheese or egg white protein, with or without glucose in type II diabetic subjects.  Metabolism  41:1137-1145, 1992.

Nuttall FQ, Gannon MC, Burmeister LA, Lane JT, and Pyzdrowski KL: The metabolic response to various doses of fructose in type II diabetic subjects.  Metabolism  41:510-517, 1992.

Lane JT, Godbole M, Strait KA, Schwartz HL, and Oppenheimer JH:  Prolonged fasting reduces rat hepatic b1 thyroid hormone receptor protein without changing the level of its mRNA.  Endocrinology  129:2881-2885, 1991

Lane JT, Subbaiah PV, Otto ME, and Bagdade JD:  Lipoprotein composition and HDL particle size distribution in women with non-insulin-dependent diabetes mellitus and the effects of probucol treatment.  J Lab Clin Med  118:120-128, 1991. 

Oppenheimer JH, Schwartz HL, Lane JT, Thompson MP:  Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat.  J Clin  Invest   87:125-132, 1991.

Lane JT, Boudreau RJ, Kinlaw WB:  Disappearance of muscular calcium deposits during resolution of prolonged rhabdomyolysis-induced hypercalcemia.  Am J Med  89:523-525, 1990.

Bagdade JD, Lane JT, Stone N, Ritter MC, Subbaiah PV:  Persistent abnormalities in lipoprotein composition and cholesteryl ester transfer following lovastatin treatment.  J of Lipid Res  31:1263-1269, 1990.

Baldwin D, Hirsch D, Lane JT:  Endocrinology, in Bone RC, Griffin K (eds.):  The Rush Internal Medicine Handbook.  Chicago, Il., Year Book Medical Publishers, Inc., 1990, pp. 229-258.

Lane JT:  Formulary, in Bone RC, Griffin K (eds):  The Rush Internal Medicine  Handbook.  Chicago, Il., Year Book Medical Publishers, Inc., 1990, pp. 281-342.