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Jianxin (Josh) Wang, MD, MS
Assistant Professor of Research

Mailing Address:
941 Stanton L. Young Blvd., BSEB 331
Oklahoma City, OK 73104-5020

(405) 271-5896 ext 47791
(405) 271-3973


Research Interests

  1. Diabetic micro vascular complications.



1991 MS - Cardiology, Sun Yat-Sen University of Medical Science, China
1985 MD - TongJi University of Medical Science,YunYang Medical College, China


Recent Publications

Zhong Y, Li J, Chen Y, Wang JJ, Ratan R, and Zhang SX. (2012). Activation of Endoplasmic Reticulum Stress by Hyperglycemia is Essential for Müller cell-derived Inflammatory Cytokine Production in Diabetes. Diabetes, Epub January 6 doi: 10.2337/db11-0315.

Jing G, Wang JJ, and Zhang SX. (2012). ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death. Exp Diabetes Res. 2012:589589.
Zhong Y, Wang JJ and Zhang SX. (2012). Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytes. Adv Exp Med Biol. 723:285-92.

Li J, Wang JJ, Zhang SX. (2011). Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1. J Biol Chem. 286(6):4912-21.

Li J, Wang JJ, Yu Q, Chen K, Mahadev K,  and Zhang SX. (2010.) Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4. Diabetes 59(6):1528-38. 

Wang M, Wang JJ, Li J, Park K, Qian X, Ma Jx, and Zhang SX. (2009.) Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. Am J Physiol Endocrinol Metab 297(6):E1378-87.

Li J, Wang JJ, Yu Q, Wang M, and Zhang SX.  (2009.) Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Letters 583:1521-1527.

Li J, Wang JJ (co-first author), Chen D, Mott R, Yu Q, Ma J-X, and Zhang SX. (2009.) Systemic Administration of HMG CoA Reductase Inhibitor Protects the Blood-retinal Barrier and Ameliorates Retinal Inflammation in Type 2 diabetes. Experimental Eye Research  Feb 28. [Epub ahead of print].

Yu Y, Jenkins A, Nankervis A, Hanssen K, Scholz H, Henriksen T, Lorentzen B, Clansen T, Garg S, Menard M, Hammad S, Scardo J, Stanley J, Dashti A, May K, Lu K, Aston C, Wang JJ, Zhang SX, Ma J-X, and Lyons T. (2009.) Anti-Angiogenic Factors and Preeclampsia in Type 1 Diabetes. Diabetologia  52:160-168.

Zhang SX, Wang J, Dashti A, Wilson K, Szweda L, Zou MH, Ma JX, and Lyons T. (2008.) Pigment epithelium-derived factor (PEDF) mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized-LDL. J Mol Endocrinol, Jun 27. [Epub ahead of print].

Wang JJ, Zhang SX, Mott R, Chen Y, Knapp RR, Cao W, and Ma J-x. (2008.) Anti-inflammatory effects of Pigment epithelium-derived factor in Diabetic Nephropathy. Am J Physiol Renal Physiol . May, 294(5):F1166-73.

Zhang SX, Wang JJ, Gao G, Park K, and Ma JX.  (2006.) Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol, 37(1):1-12.

Wang JJ, Zhang SX, Mott R, Knapp RR, Cao W, Lau K, and Ma J-X. (2006.) Salutary Effect of Pigment Epithelium-Derived Factor in Diabetic Nephropathy: Evidence for Anti-fibrogenic Activities. Diabetes, Jun; 55(6):1678-85.

Zhang SX, Wang JJ, Gao G, Mott, R, and Ma J-x. (2006.) Pigment epithelium-derived factor (PEDF) is a novel anti-inflammatory factor inhibiting vascular leakage in diabetic retinopathy. FASEB J., 20:323-325.

Wang JJ* (co-first author), Zhang SX,  Lu K, Mott R, and Ma J-x. (2006.) Therapeutic Potential of Angiostatin in Diabetic Nephropathy. J Am Soc Nephro, 17:475-486.

*Comment in (Editorial): Zent R., Pozzi A. (2006.) Antiangiogenic therapy in diabetic nephropathy. J Am Soc Nephrol. 17(2):325-27.

Wang JJ, Zhang SX, Lu K, Chen Y, Mott R, Sato S, and Ma J-x. (2005.) Decreased Expression of Pigment Epithelium-derived Factor Is Involved in the Pathogenesis of Diabetic Nephropathy. Diabetes, 54(1):243-50.

Zhang SX, Sima J, Wang JJ, Shao C, Fant J, and Ma J-x. (2005.) Systemic and periocular delivery of plaseminogen kringle 5 reduces vascular leakage in rat models of oxygen-induced retinopathy and diabetes. Curr. Eye Res., 30,681-689.


Reviews and Invited Papers

Ma Jx, Zhang SX, Wang JJ.  Down-regulation of Angiogenic Inhibitors: A New  Pathogenic Mechanism For Diabetic Complications. Invited Review Curr Diabetes Rev. 1, 183-196, 2005.


Conference Presentations

Wang JJ, Wang M, Li J and Zhang SX.(2010.)Induction of Anti-oxidant Genes by X-box Binding Protein 1 Protects Vascular Endothelial Cells against Oxidative Stress and Inflammation. American Diabetes Association 70th Scientific Sessions,Orlando, FL.

Zhang SX,  Li J and  Wang JJ. (2010.) Macrophage metalloelastase (MMP-12) deficiency mitigates inflammation and pathological angiogenesis in ischemic retinopathy. American Diabetes Association 70th Scientific Sessions,Orlando, FL.

Wang JJ,  Zhong Y,  Li J and  Zhang SX.(2010.)Activation of Endoplasmic Reticulum Stress by Hyperglycemia is Essential for Inflammatory Cytokine Production in Müller cells in Diabetes. XIX Biennial Meeting of the International Society for Eye Research, Montreal, Canada.

Wang JJ, Wang M, Li J, Park K, Ma J-x, and Zhang SX. (2009.) Pigment Epithelium-derived factor (PEDF) suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes.  American Diabetes Association 69th Scientific Sessions, New Orleans, LA.

Wang JJ, Zhang SX, Mott R, Zhang B, Eby B, Lau K, and Ma J-x. (2008.) Benificial effects of Kallikrein Binding Protein on  Diabetic  Nephropathy. American Diabetes Association 68th Scientific Sessions, San Francisco, CA.

Wang JJ, Zhang SX, Chen Y, Mott R, Eby B, Lau K and Ma J-X. (2006.) Pigment epithelium-derived factor attenuates renal inflammation and albuminuria in streptozotocin-induced diabetic rats. American Diabetes Association 66th Scientific Sessions, Washington D.C.

Zhang SX, Wang JJ, Lu K, Mott R, and Ma J-X. (2005.) Therapeutic Potential of  Angiostatin in Diabetic Nephropathy. American Diabetes Association 65th Scientific Sessions, San Diego, CA.

Wang JJ, Zhang SX, Lu K,Chen Y, Mott R, and Ma J-X. (2005.) Beneficial effect of pigment epithelium-derived factor on diabetic nephropathy. American Diabetes Association 65th Scientific Sessions, San Diego, CA.

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The University of Oklahoma Health Sciences Center

Endocrinology and Diabetes
1000 N. Lincoln Blvd.; Harold Hamm Diabetes Center Building #2900
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Phone - (405) 271-5896
FAX - (405) 271-7522

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