Xichun Yu, MD Assistant Research Professor
Mailing Address: Everett Tower/University Hospital 1200 N. Everett Drive, ET 6E103 Oklahoma City, OK 73104-5068	Telephone: (405) 271-5896 ext 47779 Fax: (405) 271-7455
Email: xichun-yu@ouhsc.edu

Research Interests

1. G protein receptor kinase 2 (GRK2) and the development of lethal ventricular tachyarrhythmias after myocardial ischemia.
2. Autonomic denervation and altered signal transduction in the development of diabetic cardiomyopathy.
3. G-protein receptor autoimmunity in cardiomyopathy and cardiac arrhythmias.

Education

Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Lazzara R, and Yu X. (2010). Opposing cardiac effects of autoantibody activation of beta-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol. Jan 5. [Epub ahead of print].

Yu X, and Kem DC. (2010). Proteasome inhibition during myocardial infarction. Cardiovasc Res 85(2):312-320.

Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, and Kem DC. (2009). Activating autoantibodies to the beta1-adrenergic and M2 muscarinic receptors facilitate atrial fibrillation in patients with Graves’ hyperthyroidism. J Am Coll Cardiol 54(14):1309-1316.

Yu X, Patterson E, and Kem DC. (2009). Targeting proteasomes for cardioprotection. Curr Opin Pharmacol 9(2):167-172.

Yu X, Patterson E, Stavrakis S, Huang S, De Aos I, Hamlett S, Cunningham MW, Lazarra R, and Kem DC. (2009). Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors. J Am Soc Hypertens 3(2):133-140.

Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, and Cunningham MW. (2008). Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity 41(6):442-453.

Huang S, Patterson E, Yu X, Garrett MW, De Aos I, and Kem DC. (2008). Proteasome inhibition one hour following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol 294(3):H1298-1303.

Kem DC, Yu X, Patterson E, Huang S, Stavrakis S, Szabo B, Olansky L, McCauley J, and Cunningham MW. (2007). Autoimmune hypertensive syndrome. Hypertension 50(5):829-34.

Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, and Yu X. (2007). Is pseudocushings syndrome in a critically ill patient pseudo? Endocr Pract 13(2):153-158.

Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, and Kem DC. (2007). Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol 6:6.

Patterson E, Yu X, Huang S, Garrett MW, and Kem DC. (2006). Suppression of autonomic-mediated triggered firing in pulmonary veins, 24 hrs post coronary artery ligation in the dog. J Cardiovasc Electrophysiol 17(7):763-770.

Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, and Kem DC. (2005). Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol 289(5):H1960-967.

Yu X, Patterson E, Huang S, Garrett MW, and Kem DC. (2005). Tumor necrosis factor alpha, rapid ventricular tachyarrhythmias and infarct size in canine models of myocardial infarction. J Cardiovasc Pharmacol 45(2):153-159.

Kem DC, Lyons DF, Wenzl J, Halverstadt D, and Yu X. (2005). Renin-dependent hypertension caused by nonfocal stenotic aberrant renal arteries: proof of a new syndrome. Hypertension 46(2):380-385.