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Harold Hamm Diabetes Center
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Miao Zhang, MD, PhD
Instructor of Research

Mailing Address:
941 Stanton L. Young Blvd., BSEB 306
Oklahoma City, OK 73104

(405) 271-5896 ext 48288
(405) 271-7522


Research Interests

  1. Diabetes and related cardiovascular disease, especially in relation to signal transduction.



2001 PhD - Toyama Medical & Pharmaceutical University, Toyama, Japan
1992 MD - Beijing Medical University, Beijing, China


Recent Publications

Dong Y, Zhang M, Wang S, Zhao Z, Chao L, Wu M, Choi HC, Lyons TJ, and Zou MH. (2010). Activation of AMP-activated Protein Kinase inhibits oxidized Low Density Lipoprotein-triggered Endoplasmic Reticulum (ER) stress and endothelium dysfunction in vivoDiabetes, ePub ahead of print, Mar 18 2010.

Dong Y, Zhang M, Liang B, Xie Z, Choi H, and Zou MH. Reduction of AMP-activated protein kinase alpha 2 increased endoplasmic reticulum stress and atherosclerosis in vivo. Circulation. In press.

Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, Zou MH. Tromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res. 2008 Feb 15;102(3):328-37.

Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, and Zou MH. Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J. Biol. Chem, 10.1074/jbc.M803020200. Published online ahead of print May 12, 2008.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner.Circulation. Circulation. 2007 Oct 2;116(14):1585-95.

Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.Circulation. 116(8):944-53, 2007.

An Z, Wang H, Song P, Zhang M, Geng X, Zou MH. Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes: A ROLE FOR OXIDANT STRESS. J Biol Chem. 14;282(37):26793-801, 2007.

Wu Y, Song P, Xu J, Zhang M, Zou MH. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem. 282(13):9777-88, 2007.

Nie H, Wu JL, Zhang M, Xu J, Zou MH. Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. Diabetes. 55(11):3133-41, 2006.

Xie Z, Davis B, Zhang M, Cui MZ, Riek U, Neumann D, Shi C, Hou X, Cohen R, Zou MH. Activation of Protein Kinase-C By Peroxynitrite Regulates      LKB1-dependent AMP-activated Protein Kinase In Endothelial cells. J. Biol Chem. 281:6366-75, 2006.

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The University of Oklahoma Health Sciences Center

Endocrinology and Diabetes
1000 N. Lincoln Blvd.; Harold Hamm Diabetes Center Building #2900
Oklahoma City, OK 73104
Phone - (405) 271-5896
FAX - (405) 271-7522

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