Ying Chen, MD, PhD Instructor of Research
Mailing Address: 941 Stanton L. Young Blvd., BSEB 332 Oklahoma City, OK 73104-5020	Telephone: (405) 271-5896 ext 48422 Fax: (405) 271-3973
Email: ying-chen@ouhsc.edu

Research Interests

1. Microinjection
2. Microsurgery
3. Gene Therapy of Ocular Diseases

Education

Chen Y, Hu Y, Moiseyev G, Zhou KK, Chen D, Ma JX.  Early Cone Degeneration and Retinal Inflammation in Very Low-density Lipoprotein Receptor Gene Knockout (Vldlr-/-) Mouse. 2008 submitted.

Wu M, Chen Y, Wilson K, Chirindel A, Ihnat M, Yu Y, Boulton ME, Szweda LI, Ma JX, Lyons TJ. Intra-retinal Leakage and Oxidation of LDL in Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2008 Mar 24; [Epub ahead of print] article link

Chen Y, Znoiko S, Degrip WJ, Crouch RK, Ma JX. Salamander Blue-sensitive Cones Lost During Metamorphosis.  Photochem Photobiol. 2008 Mar 7; [Epub ahead of print] article link

Wang JJ, Zhang SX, Mott R, Chen Y, Knapp RR, Cao W, Ma JX. Anti-inflammatory Effects of Pigment Epithelium-derived Factor in Diabetic Nephropathy. Am J Physiol Renal Physiol. 2008 Mar 5; [Epub ahead of print] article link

Moiseyev G, Takahashi Y, Chen Y, Kim S, Ma JX. RPE65 from Cone-dominant Chicken Is a More Efficient Isomerohydrolase Compared with That from Rod-dominant Species. J Biol Chem. 2008 Mar 28; 283(13):8110-7. article link

Chen Y, Hu Y, Lu K, Flannery JG, Ma JX. VLDLR, a Negative Regulator of the Wnt Signaling Pathway in Choroidal Neovascularization. (2007). J Biol Chem. 282(47):34420-8.

Park K, Chen Y, Mayo AS, Kompella UB, Hu Y, Longeras R,Ma JX. Effect of Nanoparticle-mediated K5 Gene Delivery on Ischemia-induced Retinal Neovascularization and Vascular Leakage. Submitted, 2007. 

Chen Y, Moiseyev G, Takahashi Y, Ma JX. Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65. FEBS Lett. Jul 24;580(17):4200-4, 2006. article link

Le YZ, Ash JD, Al-Ubaidi MR, Chen Y, Ma JX, Anderson RE. Conditional gene knockout system in cone photoreceptors. Adv Exp Med Biol. 572:173-8, 2006. article link

Takahashi Y, Moiseyev G, Chen Y, Ma JX. The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Invest Ophthalmol Vis Sci. 47:5191-6, 2006. article link

Isayama T, Chen Y, McCabe SL, DeGrip WJ, Zimmerman AL, Ma JX & Crouch RK and Makino CL. Differences in the pharmacological activation of visual opsins support the existence of a second retinoid-binding site.  Visual Neuroscience. 23:899-908, 2006.

Takahashi Y, Chen Y, Moiseyev G, Ma JX. Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. J Biol Chem. 281:21820-6, 2006.

Moiseyev, G., Takahashi, Y., Chen, Y., Gentleman, S., T.M., Redmond, Crouch, R.K. and Ma, J-X. RPE65 is an Iron(II)-dependent Isomerohydrolase in the Retinoid Visual Cycle. J. Biol. Chem 281, 2835-3840, 2006.

Chen, Y., Moiseyev, G., Takahashi, Y. and Ma, J-X. RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest. Ophthalmol. Vis. Sci. 47:1177-84, 2006.