YOU ARE HERE : Endocrinology and Diabetes / : Faculty : R. Hal Scofield, MD - Professor, Director of Fellowship Program
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R. Hal Scofield, MD
Professor

 

Dr. Scofield's Research Group

Hal ScofieldLarge
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Mailing Address:
OMRF

825 NE 13th St. - MS 24

Oklahoma City, OK 73104

Telephone:
(405) 271-7144
Fax:
(405) 271-4110
Email: hal-scofield@omrf.ouhsc.edu  

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Research Interests

The immune system distinguishes self from non-self. In autoimmunity, this ability fails. My research concentrates on the systemic autoimmune diseases, systemic lupus erythematosus and Sjögren's syndrome, which are characterized by a loss of tolerance to the ubiquitous antigens Ro/SSA and La/SSB. We use a wide range of scientific disciplines, from clinical research to laboratory-based basic research to animal models of human disease.

Presently we are studying a powerful genetic association on chromosome 11 at p13 that was originally found in families with severe SLE that are ethnically identified as Black Americans. High density single nucleotide polymorphism typing has identified a highly promising candidate gene, which is now being pursued with studies designed to explore the mechanism by which SLE susceptibility is increased. The etiology for the preponderance of women with SLE is under study. We have found that Klinefelter's syndrome (male 47, XXY) is found in excess among men with SLE, while 47,XXX is increased among women with SLE. Genetic linkage on X is established and is being further defined to test the hypothesis of a gene dose effect. Other genetic interests include the relationship of prolidase deficiency to systemic autoimmunity, and the genetics of Sjögren's syndrome.  We are in the process of finalizing the first genome-wide association study for this disease.

My laboratory is also interested in the immunology of systemic lupus erythematosus and Sjögren's syndrome. Immunization of animals with short peptides from 60 kD Ro induces epitope spreading as well as a Sjögren's syndrome-like illness. The immunology and genetics of this model are being explored. Future studies of this model include adoptive transfer, genetic control of epitope spreading as well as disease manifestations, MRI imaging of animals, and prevention by dendritic cell immunization. This project complements animal immunization studies in which oxidatively modified antigens induce enhanced epitope spreading and disease.  We also find that humans with SLE have more oxidative modification of proteins and lipids than do controls. 

Human lupus and Sjögren's are being studied at the level of B cell immunity.  We have found that transfer of anti-Ro antibodies into naïve animals induces salivary gland dysfunction.  The mechanism of this pathology is being investigated, including in 60 kD Ro knock out animals.   

Clinical research involving diabetes among patients with lupus is ongoing.  In addition, clinical research is being pursued in a comprehensive Sjögren's syndrome research clinic in which patients undergo a complete dental, ophthalmological, and medical evaluation. 

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Education

1989-1991 Associate Research Scientist, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
1988-1991 Fellow, Section of Endocrinology, Metabolism and Hypertension, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK
1987-1988 Chief Medical Resident, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK
1984-1987 Resident in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK
1980-1984 MD - University of Texas Southwestern Medical School, Dallas, TX
1976-1980 BA - Chemistry, Texas A&M University, College Station, TX

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Recent Publications

LaBryer, L., Sharma, R., Chaudhari, K. S., Talsania, M. S., Scofield, R. H. (2018). Kratom, an Emerging Drug of Abuse, Raises Prolactin and Causes Secondary Hypogonadism: Case Report. Journal of investigative medicine high impact case reports, 6, 2324709618765022. PMID: 29568783. DOI: 10.1177/2324709618765022Radfar L, Scofield RH. Kikuchi-Fujimoto Disease in Patients with Sjögren’s Syndrome. Open J Pathol 3:32-36, 2013

Koelsch, K. A., Cavett, J., Smith, K. M., Moore, J. S., Lehoux, S. D., Jia, N., Mather, T., Quadri SMS, Rasmussen, A., Kaufman, C. E., Lewis, D. M., Radfar, L., Scordino, T. A., Lessard, C. J., Kurien, B. T., Cummings, R. D., James, J. A., Sivils, K. L., Darise Farris, A., Scofield, R. H. (2018). Evidence for Alternate Modes of B cell Activation Involving Fab Acquired-N-Glycosylations in Antibody Secreting Cells Infiltrating the Labial Salivary Glands of Sjögren's Syndrome Patients. Arthritis & rheumatology (Hoboken, N.J.). PMID: 29457375. DOI: 10.1002/art.40458

Basu, A., Schell, J., Scofield, R. H. (2018). Dietary fruits and arthritis. Food & function, 9(1), 70-77. PMID: 29227497. DOI: 10.1039/c7fo01435j

Sharma, R., Harris, V. M., Cavett, J., Kurien, B. T., Liu, K., Koelsch, K. A., Fayaaz, A., Chaudhari, K. S., Radfar, L., Lewis, D., Stone, D. U., Kaufman, C. E., Li, S., Segal, B., Wallace, D. J., Weisman, M. H., Venuturupalli, S., Kelly, J. A., Pons-Estel, B., Jonsson, R., Lu, X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang AJW, Brennan, M. T., Hughes, P., Alevizos, I., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Nordmark, G., Bucher, S. M., Eriksson, P., Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Wahren-Herlenius, M., Witte, T., Alarcón-Riquelme, M., Mariette, X., Lessard, C. J., Harley, J. B., Ng, W. F., Rasmussen, A., Sivils, K. L., Scofield, R. H. (2017). Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome. Arthritis & rheumatology (Hoboken, N.J.), 69(11), 2187-2192. PMID: 28692793. DOI: 10.1002/art.40207

Leehan, K. M., Pezant, N. P., Rasmussen, A., Grundahl, K., Moore, J. S., Radfar, L., Lewis, D. M., Stone, D. U., Lessard, C. J., Rhodus, N. L., Segal, B. M., Scofield, R. H., Sivils, K. L., Montgomery, C., Farris, A. D. (2017). Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging. Clinical and experimental rheumatology. PMID: 29148407

Talsania, M. S., Sharma, R., Sughrue, M. E., Scofield, R. H., Lim, J. (2017). Familial Pallister-Hall in adulthood. Neuro endocrinology letters, 38(5), 329-331. PMID: 29106787.

Schell, J., Betts, N. M., Foster, M., Scofield, R. H., Basu, A. (2017). Cranberries improve postprandial glucose excursions in type 2 diabetes. Food & function, 8(9), 3083-3090. PMID: 28748974. DOI: 10.1039/c7fo00900c

Schell, J., Scofield, R. H., Barrett, J., Kurien, B. T., Betts, N., Lyons, T. J., Zhao, Y. D., Basu, A. (2017). Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis. Nutrients, 9(9). PMID: 28846633. DOI: 10.3390/nu9090949

Li, H., Reksten, T. R., Ice, J. A., Kelly, J. A., Adrianto, I., Rasmussen, A., Wang, S., He, B., Grundahl, K. M., Glenn, S. B., Miceli-Richard, C., Bowman, S., Lester, S., Eriksson, P., Eloranta, M. L., Brun, J. G., Gøransson, L. G., Harboe, E., Guthridge, J. M., Kaufman, K. M., Kvarnström, M., Cunninghame Graham, D. S., Patel, K., Adler, A. J., Farris, A. D., Brennan, M. T., Chodosh, J., Gopalakrishnan, R., Weisman, M. H., Venuturupalli, S., Wallace, D. J., Hefner, K. S., Houston, G. D., Huang AJW, Hughes, P. J., Lewis, D. M., Radfar, L., Vista, E. S., Edgar, C. E., Rohrer, M. D., Stone, D. U., Vyse, T. J., Harley, J. B., Gaffney, P. M., James, J. A., Turner, S., Alevizos, I., Anaya, J. M., Rhodus, N. L., Segal, B. M., Montgomery, C. G., Scofield, R. H., Kovats, S., Mariette, X., Rönnblom, L., Witte, T., Rischmueller, M., Wahren-Herlenius, M., Omdal, R., Jonsson, R., Ng, W. F., Nordmark, G., Lessard, C. J., Sivils, K. L. (2017). Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS genetics, 13(6), e1006820. PMID: 28640813. DOI: 10.1371/journal.pgen.1006820

Brito-Zerón, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Theander, E., Li, X., Baldini, C., Gottenberg, J. E., Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A. A., Valim, V., Kvarnstrom, M., Sene, D., Gerli, R., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Kwok, S. K., Nordmark, G., Suzuki, Y., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Hofauer, B., Bootsma, H., Brun, J. G., Fraile, G., Carsons, S. E., Gheita, T. A., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. F., Sivils, K., Mandl, T., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Trevisani VFM, Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., EULAR-SS Task Force Big Data Consortium (2017). Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium. Annals of the rheumatic diseases, 76(6), 1042-1050. PMID: 27899373. DOI: 10.1136/annrheumdis-2016-209952

Danda, D., Sharma, R., Truong, D., Koelsch, K. A., Kurien, B. T., Bagavant, H., Deshmukh, U., Kaufman, C. E., Lewis, D. M., Stone, D. U., Radfar, L., Rasmussen, A., Sivils, K. L., Scofield, R. H. (2017). Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? Clinical and experimental rheumatology, 35(3), 438-444. PMID: 28229827.

Talsania, M. S.*, Scofield, R. H.# (2017). Menopause and Rheumatic Disease. Rheumatic diseases clinics of North America, 43(2), 287-302. PMID: 28390570. DOI: 10.1016/j.rdc.2016.12.011

Carsons, S. E., Vivino, F. B., Parke, A., Carteron, N., Sankar, V., Brasington, R., Brennan, M. T., Ehlers, W., Fox, R., Scofield, H., Hammitt, K. M., Birnbaum, J., Kassan, S., Mandel, S. (2017). Treatment Guidelines for Rheumatologic Manifestations of Sjögren's Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain. Arthritis care & research, 69(4), 517-527. PMID: 27390247. DOI: 10.1002/acr.22968

Vitali, C., Scofield, R. H., Shiboski, S., Seror, R., Criswell, L., Labetoulle, M., Lietman, T., Rasmussen, A., Bowman, S., Mariette, X., Shiboski, C. (in press). Author’s Response to Tezcan and colleagues’ letter. Arthritis Rheumatol. DOI: 10.1002/art.40085 [Epub ahead of print]

Danda, D., Sharma, R.*, Truong, D., Koelsch, K. A., Kurien, B. T., Bagavant, H., Deshmukh, U., Kaufman, C. E., Lewis, D. M., Stone, D. U., Radfar, L., Rasmussen, A., Sivils, K. L., Scofield, R. H.# (2017). Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? Clinical and experimental rheumatology. PMID: 28229827

Stone, D. U., Fife, D., Brown, M., Earley, K. E., Radfar, L., Kaufman, C. E., Lewis, D. M., Rhodus, N. L., Segal, B. M., Wallace, D. J., Weisman, M. H., Venuturupalli, S., Brennan, M. T., Lessard, C. J., Montgomery, C. G., Scofield, R. H., Sivils, K. L., Rasmussen, A. (2017). Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjögren's Syndrome. PloS one, 12(2), e0170249. PMID: 28166540. DOI: 10.1371/journal.pone.0170249

Shiboski, C. H., Shiboski, S. C., Seror, R., Criswell, L. A., Labetoulle, M., Lietman, T. M., Rasmussen, A., Scofield, H., Vitali, C., Bowman, S. J., Mariette, X. (2017). 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis & rheumatology (Hoboken, N.J.), 69(1), 35-45. PMID: 27785888. DOI: 10.1002/art.39859

Kurien, B. T., Matsumoto, H., Scofield, R. H. (2017). Nutraceutical Value of Pure Curcumin. Pharmacognosy magazine, 13(Suppl 1), S161-S163. PMID: 28479742. DOI: 10.4103/0973-1296.203988

Kurien, B. T., Scofield, R. H. (2017). Validating Antibody Specificities for Immunohistochemistry by Protein Blotting Methods. Methods in molecular biology (Clifton, N.J.), 1554, 61-73. PMID: 28185183. DOI: 10.1007/978-1-4939-6759-9_3

Fayyaz, A.*, Scofield, R. H. (2016). Iatrogenic milk-alkali syndrome in a patient recovering from acute renal failure. J Diabetes Endocrinol, 3(3), 1-3. DOI: I: http://dx.doi.org/10.15226/2374-6890/3/3/00150

Kurien, B. T., Fesmire, J., Anderson, C. J., Scofield, R. H. (2016). Anti-Ro and Concomitant Anti-La Autoantibodies Strongly Associated With Anti-oxLDL or Anti-Phospholipid Antibody in Systemic Lupus Erythematosus. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 22(8), 418-425. PMID: 27870764. DOI: 10.1097/RHU.0000000000000429

Deng, Y., Zhao, J., Sakurai, D., Sestak, A. L., Osadchiy, V., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., James, J. A., Petri, M. A., Bae, S. C., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Criswell, L. A., Freedman, B. I., Kamen, D. L., Gilkeson, G. S., Jacob, C. O., Merrill, J., Gaffney, P. M., Sivils, K. M., Niewold, T. B., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Boackle, S. A., Vilá, L. M., Sohn, I. I., Lee, S., Chang, D. M., Song, Y. W., Vyse, T. J., Harley, J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Cantor, R. M., Hahn, B. H., Grossman, J. M., Tsao, B. P. (2016). Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Annals of the rheumatic diseases, 75(11), 2007-2013. PMID: 26783109. DOI: 10.1136/annrheumdis-2015-208441

Seror, R., Meiners, P., Baron, G., Bootsma, H., Bowman, S. J., Vitali, C., Gottenberg, J. E., Theander, E., Tzioufas, A., De Vita, S., Ramos-Casals, M., Dörner, T., Quartuccio, L., Ravaud, P., Mariette, X., EULAR Sjögren Task Force (2016). Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies. Annals of the rheumatic diseases, 75(11), 1945-1950. PMID: 27150113. DOI: 10.1136/annrheumdis-2015-208504

Fedorowski, A., Li, H., Yu, X., Koelsch, K. A., Harris, V. M.*, Liles, C., Murphy, T. A., Quadri, S. M.*, Scofield, R. H., Sutton, R., Melander, O., Kem, D. C. (2016). Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. PMID: 27702852. DOI: 10.1093/europace/euw154

Fayyaz, A.*, Kurien, B. T., Scofield, R. H.# (2016). Autoantibodies in Sjögren's Syndrome. Rheumatic diseases clinics of North America, 42(3), 419-34. PMID: 27431345. DOI: 10.1016/j.rdc.2016.03.002

Vivino, F. B., Carsons, S. E., Foulks, G., Daniels, T. E., Parke, A., Brennan, M. T., Forstot, S. L., Scofield, R. H., Hammitt, K. M. (2016). New Treatment Guidelines for Sjögren's Disease. Rheumatic diseases clinics of North America, 42(3), 531-51. PMID: 27431353. DOI: 10.1016/j.rdc.2016.03.010

Sandhya, P., Kurien, B. T., Danda, D.*, Scofield, R. H.# (2016). Update on Pathogenesis of Sjögren's syndrome. Current rheumatology reviews. PMID: 27412602

Harris, V. M.*, Sharma, R.*, Cavett, J., Kurien, B. T., Liu, K.*, Koelsch, K. A., Rasmussen, A., Radfar, L., Lewis, D., Stone, D. U., Kaufman, C. E., Li, S., Segal, B., Wallace, D. J., Weisman, M. H., Venuturupalli, S., Kelly, J. A., Alarcon-Riquelme, M. E., Pons-Estel, B., Jonsson, R., Lu, X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang, A. J., Brennan, M. T., Hughes, P., Alevizos, I., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Xie, G., Ng, W. F., Nordmark, G., Bucher, S. M., Eriksson, P., Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Wahren-Herlenius, M., Witte, T., Mariette, X., Lessard, C. J., Harley, J. B., Sivils, K. L., Scofield, R. H. (2016). Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome. Clinical immunology (Orlando, Fla.), 168, 25-9. PMID: 27109640. DOI: 10.1016/j.clim.2016.04.002

Rasmussen, A., Radfar, L., Lewis, D., Grundahl, K., Stone, D. U., Kaufman, C. E., Rhodus, N. L., Segal, B., Wallace, D. J., Weisman, M. H., Venuturupalli, S., Kurien, B. T., Lessard, C. J., Sivils, K. L., Scofield, R. H. (2016). Previous diagnosis of Sjögren's Syndrome as rheumatoid arthritis or systemic lupus erythematosus. Rheumatology (Oxford, England), 55(7), 1195-201. PMID: 26998859. DOI: 10.1093/rheumatology/kew023

Joachims, M. L.*, Leehan, K. M.*, Lawrence, C. A., Pelikan, R. C., Moore, J. S., Pan, Z., Rasmussen, A., Radfar, L., Lewis, D. M., Grundahl, K. M., Kelly, J. A., Wiley, G. B., Shugay, M., Chudakov, D. M., Lessard, C. J., Stone, D. U., Scofield, R. H., Montgomery, C. G., Sivils, K. L., Thompson, L. F., Farris, A. D. (2016). Single-cell analysis of glandular T cell receptors in Sjögren's syndrome. JCI insight, 1(8). PMID: 27358913. DOI: 10.1172/jci.insight.85609

Liu, K.*, Kurien, B. T., Zimmerman, S. L., Kaufman, K. M., Taft, D. H., Kottyan, L. C., Lazaro, S., Weaver, C. A., Ice, J. A., Adler, A. J., Chodosh, J., Radfar, L., Rasmussen, A., Stone, D. U., Lewis, D. M., Li, S., Koelsch, K. A., Igoe, A., Talsania, M. S., Kumar, J., Maier-Moore, J. S., Harris, V. M., Gopalakrishnan, R., Jonsson, R., Lessard, J. A., Lu, X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang, A. J., Brennan, M. T., Hughes, P., Illei, G. G., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Xie, G., Ng, W. F., Nordmark, G., Eriksson, P., Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Segal, B. M., Vyse, T. J., Wahren-Herlenius, M., Witte, T., Pons-Estel, B., Alarcón-Riquelme, M. E., Guthridge, J. M., James, J. A., Lessard, C. J., Kelly, J. A., Thompson, S. D., Gaffney, P. M., Montgomery, C. G., Edberg, J. C., Kimberly, R. P., Alarcón, G. S., Langefeld, C. L., Gilkeson, G. S., Kamen, D. L., Tsao, B. P., Joseph McCune, W., Salmon, J. E., Merrill, J., Weisman, M. H., Wallace, D. J., Utset, T. O., Bottinger, E. P., Amos, C. I., Siminovitch, K. A., Mariette, X., Sivils, K. L., Harley, J. B., Scofield, R. H. (2016). X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome. Arthritis & rheumatology (Hoboken, N.J.), 68(5), 1290-300. PMID: 26713507. DOI: 10.1002/art.39560

Wolska, N.*, Rybakowska, P., Rasmussen, A., Brown, M., Montgomery, C., Klopocki, A., Grundahl, K., Scofield, R. H., Radfar, L., Stone, D. U., Anaya, J. M., Ice, J. A., Lessard, C. J., Lewis, D. M., Rhodus, N. L., Gopalakrishnan, R., Huang, A. J., Hughes, P. J., Rohrer, M. D., Weisman, M. H., Venuturupalli, S., Guthridge, J. M., James, J. A., Sivils, K. L., Bagavant, H., Deshmukh, U. S. (2016). Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity. Arthritis & rheumatology (Hoboken, N.J.), 68(3), 724-9. PMID: 26636433. DOI: 10.1002/art.39497

Szczerba, B. M.*, Kaplonek, P., Wolska, N., Podsiadlowska, A., Rybakowska, P. D., Dey, P., Rasmussen, A., Grundahl, K., Hefner, K. S., Stone, D. U., Young, S., Lewis, D. M., Radfar, L., Scofield, R. H., Sivils, K. L., Bagavant, H., Deshmukh, U. S. (2016). Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice. Annals of the rheumatic diseases, 75(3), 617-22

Zhao, J., Giles, B. M., Taylor, R. L., Yette, G. A., Lough, K. M., Ng, H. L., Abraham, L. J., Wu, H., Kelly, J. A., Glenn, S. B., Adler, A. J., Williams, A. H., Comeau, M. E., Ziegler, J. T., Marion, M., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Bae, S. C., Kim, D., Lee, H. S., Criswell, L. A., Freedman, B. I., Gilkeson, G. S., Guthridge, J. M., Jacob, C. O., James, J. A., Kamen, D. L., Merrill, J., Sivils, K. M., Niewold, T. B., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Vilá, L. M., Vyse, T. J., Kaufman, K. M., Harley, J. B., Langefeld, C. D., Gaffney, P. M., Brown, E. E., Edberg, J. C., Kimberly, R. P., Ulgiati, D., Tsao, B. P., Boackle, S. A. (2016). Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Annals of the rheumatic diseases, 75(1), 242-52. PMID: 25180293. DOI: 10.1136/annrheumdis-2014-205584

Zhao, J., Wu, H., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Bae, S. C., Alarcón, G. S., Anaya, J. M., Criswell, L. A., Freedman, B. I., Kamen, D. L., Gilkeson, G. S., Jacob, C. O., James, J. A., Merrill, J., Gaffney, P. M., Sivils, K. M., Niewold, T. B., Petri, M. A., Song, S. T., Jeong, H. J., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Boackle, S. A., Vilá, L. M., Chang, D. M., Song, Y. W., Vyse, T. J., Harley, J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Hahn, B. H., Grossman, J. M., Tsao, B. P., La Cava, A. (2015). Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clinical immunology (Orlando, Fla.), 161(2), 157-62. PMID: 26385092. DOI: 10.1016/j.clim.2015.09.007

Radfar, L., Ahmadabadi, R. E., Masood, F., Scofield, R. H.# (2015). Biological therapy and dentistry: a review paper. Oral surgery, oral medicine, oral pathology and oral radiology, 120(5), 594-601. PMID: 26372436. DOI: 10.1016/j.oooo.2015.07.032

Kurien, B. T., Harris, V. M.*, Quadri, S. M.*, Coutinho-de Souza, P., Cavett, J., Moyer, A., Ittiq, B., Metcalf, A., Ramji, H. F., Truong, D., Kumar, R., Koelsch, K. A., Centola, M., Payne, A., Danda, D., Scofield, R. H. (2015). Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment. Lupus science & medicine, 2(1), e000114. PMID: 26380101. DOI: 10.1136/lupus-2015-000114

Sandhya, P., Jeyaseelan, L., Scofield, R. H., Danda, D. (2015). Clinical Characteristics and Outcome of Primary Sjogren's Syndrome: A Large Asian Indian Cohort. The open rheumatology journal, 9, 36-45. PMID: 26161156. DOI: 10.2174/1874312901409010036

Lu, X.*, Zoller, E. E., Weirauch, M. T., Wu, Z., Namjou, B., Williams, A. H., Ziegler, J. T., Comeau, M. E., Marion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S. K., Stevens, A. M., Freedman, B. I., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S., Alarcón, G. S., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L., Criswell, L. A., Vilá, L. M., Alarcón-Riquelme, M. E., Petri, M., Scofield, R. H., Kimberly, R. P., Ramsey-Goldman, R., Joo, Y. B., Choi, J., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Guthridge, J. M., Gaffney, P. M., Langefeld, C. D., Kelly, J. A., Greis, K. D., Kaufman, K. M., Harley, J. B., Kottyan, L. C. (2015). Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression. American journal of human genetics, 96(5), 731-9. PMID: 25865496. DOI: 10.1016/j.ajhg.2015.03.002

Clark, E. G., Knoll, G., Bugeja, A., Burns, K. D., Scofield, R. H. (2015). Lupus after kidney donation to an affected male relative. Transplantation, 99(4), e27-8. PMID: 25827324. DOI: 10.1097/TP.0000000000000643

Maier-Moore, J. S.*, Kurien, B. T., D'Souza, A., Bockus, L., Asfa, S., Dorri, Y., Hubbell, S., Yeliosof, O.*, Obeso, D.*, Schoeb, T. R., Jonsson, R., Scofield, R. H.# (2015). Passive transfer of antibodies to the linear epitope 60kD Ro 273-289 induces features of Sjögren's syndrome in naive mice. Clinical and experimental immunology, 180(1), 19-27. PMID: 25370295. DOI: 10.1111/cei.12480

Fayyaz, A.*, Igoe, A.*, Kurien, B. T., Danda, D.*, James, J. A., Stafford, H. A., Scofield, R. H. (2015). Haematological manifestations of lupus. Lupus science & medicine, 2(1), e000078. PMID: 25861458. DOI: 10.1136/lupus-2014-000078

Seror, R., Bowman, S. J., Brito-Zeron, P., Theander, E., Bootsma, H., Tzioufas, A., Gottenberg, J. E., Ramos-Casals, M., Dörner, T., Ravaud, P., Vitali, C., Mariette, X., Asmussen, K., Jacobsen, S., Bartoloni, E., Gerli, R., Bijlsma, J. W., Kruize, A. A., Bombardieri, S., Bookman, A., Kallenberg, C., Meiners, P., Brun, J. G., Jonsson, R., Caporali, R., Carsons, S., De Vita, S., Del Papa, N., Devauchelle, V., Saraux, A., Fauchais, A. L., Sibilia, J., Hachulla, E., Illei, G., Isenberg, D., Jones, A., Manoussakis, M., Mandl, T., Jacobsson, L., Demoulins, F., Montecucco, C., Ng, W. F., Nishiyama, S., Omdal, R., Parke, A., Praprotnik, S., Tomsic, M., Price, E., Scofield, H., Sivils, K., Smolen, J., Laqué, R. S., Steinfeld, S., Sutcliffe, N., Sumida, T., Valesini, G., Valim, V., Vivino, F. B., Vollenweider, C. (2015). EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide. RMD open, 1(1), e000022. PMID: 26509054. DOI: 10.1136/rmdopen-2014-000022

Kottyan, L. C., Zoller, E. E., Bene, J., Lu, X., Kelly, J. A., Rupert, A. M., Lessard, C. J., Vaughn, S. E., Marion, M., Weirauch, M. T., Namjou, B., Adler, A., Rasmussen, A., Glenn, S., Montgomery, C. G., Hirschfield, G. M., Xie, G., Coltescu, C., Amos, C., Li, H., Ice, J. A., Nath, S. K., Mariette, X., Bowman, S., Rischmueller, M., Lester, S., Brun, J. G., Gøransson, L. G., Harboe, E., Omdal, R., Cunninghame-Graham, D. S., Vyse, T., Miceli-Richard, C., Brennan, M. T., Lessard, J. A., Wahren-Herlenius, M., Kvarnström, M., Illei, G. G., Witte, T., Jonsson, R., Eriksson, P., Nordmark, G., Ng, W. F., Anaya, J. M., Rhodus, N. L., Segal, B. M., Merrill, J., James, J. A., Guthridge, J. M., Scofield, R. H., Alarcon-Riquelme, M., Bae, S. C., Boackle, S. A., Criswell, L. A., Gilkeson, G., Kamen, D. L., Jacob, C. O., Kimberly, R., Brown, E., Edberg, J., Alarcón, G. S., Reveille, J. D., Vilá, L. M., Petri, M., Ramsey-Goldman, R., Freedman, B. I., Niewold, T., Stevens, A. M., Tsao, B. P., Ying, J., Mayes, M. D., Gorlova, O. Y., Wakeland, W., Radstake, T., Martin, E., Martin, J., Siminovitch, K., Moser Sivils, K. L., Gaffney, P. M., Langefeld, C. D., Harley, J. B., Kaufman, K. M. (2015). The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Human molecular genetics, 24(2), 582-96. PMID: 25205108. DOI: 10.1093/hmg/ddu455

Vaughn, S. E., Foley, C., Lu, X., Patel, Z. H., Zoller, E. E., Magnusen, A. F., Williams, A. H., Ziegler, J. T., Comeau, M. E., Marion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S., Stevens, A. M., Freedman, B. I., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S., Alarcón, G. S., Reveille, J. D., Anaya, J. M., James, J. A., Moser, K. L., Criswell, L. A., Vilá, L. M., Alarcón-Riquelme, M. E., Petri, M., Scofield, R. H., Kimberly, R. P., Ramsey-Goldman, R., Binjoo, Y., Choi, J., Bae, S. C., Boackle, S. A., Vyse, T. J., Guthridge, J. M., Namjou, B., Gaffney, P. M., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Harley, I. T., Harley, J. B., Kottyan, L. C. (2015). Lupus risk variants in the PXK locus alter B-cell receptor internalization. Frontiers in genetics, 5, 450. PMID: 25620976. DOI: 10.3389/fgene.2014.00450

Canzler, U., Bartsch, H., Großmann, K., Lehmann, W., Conrad, K., Kurien, B. T., Dorri, Y., Scofield, R. H., Bachmann, M. P. (2015). A miniaturized blotting system for simultaneous detection of different autoantibodies. Methods in molecular biology (Clifton, N.J.), 1312, 165-73. PMID: 26044001. DOI: 10.1007/978-1-4939-2694-7_20

Kurien, B. T., Scofield, R. H. (2015). Analysis of antibody clonotype by affinity immunoblotting. Methods in molecular biology (Clifton, N.J.), 1312, 109-17. PMID: 26043996. DOI: 10.1007/978-1-4939-2694-7_15

Aggarwal, R.*, Anaya, J. M.*, Koelsch, K. A., Kurien, B. T., Scofield, R. H.# (2015). Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families. Autoimmune diseases, 2015, 298506. PMID: 26246904. DOI: 10.1155/2015/298506

LaBryer, L.*, Sawh, R., McLaurin, C., Scofield, R. H.# (2015). Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid. Case reports in endocrinology, 2015, 606389. PMID: 26491576. DOI: 10.1155/2015/606389

Yeliosof, O.*, Scofield, R. H. (2015). Grid-immunoblotting. Methods in molecular biology (Clifton, N.J.), 1312, 375-8. PMID: 26044018. DOI: 10.1007/978-1-4939-2694-7_37

Kurien, B. T., Scofield, R. H. (2015). Multiple Immunoblots by Passive Diffusion of Proteins from a Single SDS-PAGE Gel. Methods in molecular biology (Clifton, N.J.), 1312, 77-86. PMID: 26043992. DOI: 10.1007/978-1-4939-2694-7_11

Moore, J. S.*, Scofield, R. H. (2015). Nanogold Immunodetection Detection Systems for the Identification of Autoantigens by Western Blotting. Methods in molecular biology (Clifton, N.J.), 1314, 179-84. PMID: 26139266. DOI: 10.1007/978-1-4939-2718-0_19

Kurien, B. T., Scofield, R. H. (2015). Other Notable Methods of Membrane Protein Detection: A Brief Review. Methods in molecular biology (Clifton, N.J.), 1314, 357-70. PMID: 26139283. DOI: 10.1007/978-1-4939-2718-0_36

Dsouza, A., Scofield, R. H. (2015). Protein Stains to Detect Antigen on Membranes. Methods in molecular biology (Clifton, N.J.), 1314, 33-40. PMID: 26139252. DOI: 10.1007/978-1-4939-2718-0_5

Kurien, B. T., Scofield, R. H. (2015). Purification of Tryptic Digests on Polyvinylidene Difluoride Membrane. Methods in molecular biology (Clifton, N.J.), 1314, 273-7. PMID: 26139275. DOI: 10.1007/978-1-4939-2718-0_28

Kurien, B. T., Danda, D., Bachmann, M. P., Scofield, R. H. (2015). SDS-PAGE to Immunoblot in One Hour. Methods in molecular biology (Clifton, N.J.), 1312, 449-54. PMID: 26044026. DOI: 10.1007/978-1-4939-2694-7_45

Kurien, B. T., Scofield, R. H. (2015). Western blotting of high and low molecular weight proteins using heat. Methods in molecular biology (Clifton, N.J.), 1312, 247-55. PMID: 26044007. DOI: 10.1007/978-1-4939-2694-7_26

Kurien, B. T., Scofield, R. H. (2015). Western blotting: an introduction. Methods in molecular biology (Clifton, N.J.), 1312, 17-30. PMID: 26043986. DOI: 10.1007/978-1-4939-2694-7_5

Maier-Moore, J. S.*, Koelsch, K. A., Smith, K. M., Lessard, C. J., Radfar, L., Lewis, D., Kurien, B. T., Wolska, N., Deshmukh, U., Rasmussen, A., Sivils, K. L., James, J. A., Farris, A. D., Scofield, R. H. (2014). Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome. Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3445-56. PMID: 25199908. DOI: 10.1002/art.38872

Ritterhouse, L. L.*, Lu, R., Shah, H. B., Robertson, J. M., Fife, D. A., Maecker, H. T., Du, H., Fathman, C. G., Chakravarty, E. F., Scofield, R. H., Kamen, D. L., Guthridge, J. M., James, J. A. (2014). Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls. PloS one, 9(4), e94500. PMID: 24727903. DOI: 10.1371/journal.pone.0094500

Guthridge, J. M., Lu, R., Sun, H., Sun, C., Wiley, G. B., Dominguez, N., Macwana, S. R., Lessard, C. J., Kim-Howard, X., Cobb, B. L., Kaufman, K. M., Kelly, J. A., Langefeld, C. D., Adler, A. J., Harley, I. T., Merrill, J., Gilkeson, G. S., Kamen, D. L., Niewold, T. B., Brown, E. E., Edberg, J. C., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Vilá, L. M., Kimberly, R. P., Freedman, B. I., Stevens, A. M., Boackle, S. A., Criswell, L. A., Vyse, T. J., Behrens, T. W., Jacob, C. O., Alarcón-Riquelme, M. E., Sivils, K. L., Choi, J., Joo, Y. B., Bang, S. Y., Lee, H. S., Bae, S. C., Shen, N., Qian, X., Tsao, B. P., Scofield, R. H., Harley, J. B., Webb, C. F., Wakeland, E. K., James, J. A., Nath, S. K., Graham, R. R., Gaffney, P. M. (2014). Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. American journal of human genetics, 94(4), 586-98. PMID: 24702955. DOI: 10.1016/j.ajhg.2014.03.008

Altorok, N., Coit, P., Hughes, T., Koelsch, K. A., Stone, D. U., Rasmussen, A., Radfar, L., Scofield, R. H., Sivils, K. L., Farris, A. D., Sawalha, A. H. (2014). Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome. Arthritis & rheumatology (Hoboken, N.J.), 66(3), 731-9. PMID: 24574234. DOI: 10.1002/art.38264

Rasmussen, A., Ice, J. A., Li, H., Grundahl, K., Kelly, J. A., Radfar, L., Stone, D. U., Hefner, K. S., Anaya, J. M., Rohrer, M., Gopalakrishnan, R., Houston, G. D., Lewis, D. M., Chodosh, J., Harley, J. B., Hughes, P., Maier-Moore, J. S., Montgomery, C. G., Rhodus, N. L., Farris, A. D., Segal, B. M., Jonsson, R., Lessard, C. J., Scofield, R. H., Sivils, K. L. (2014). Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Annals of the rheumatic diseases, 73(1), 31-8. PMID: 23968620. DOI: 10.1136/annrheumdis-2013-203845

Radfar, L., Scofield, R. H. (2013). Kikuchi-Fujimoto Disease in Patients with Sjögren’s Syndrome. Open J Pathol, 3, 32-36

Kurien, B. T., D'Sousa, A., Bruner, B. F.*, Gross, T., James, J. A., Targoff, I. N., Maier-Moore, J. S., Harley, I. T.*, Wang, H., Scofield, R. H. (2013). Prolidase deficiency breaks tolerance to lupus-associated antigens. International journal of rheumatic diseases, 16(6), 674-80. PMID: 24330273. DOI: 10.1111/1756-185X.12254

Caster, D. J., Korte, E. A., Nanda, S. K., McLeish, K. R., Oliver, R. K., G'sell, R. T., Sheehan, R. M., Freeman, D. W., Coventry, S. C., Kelly, J. A., Guthridge, J. M., James, J. A., Sivils, K. L., Alarcon-Riquelme, M. E., Scofield, R. H., Adrianto, I., Gaffney, P. M., Stevens, A. M., Freedman, B. I., Langefeld, C. D., Tsao, B. P., Pons-Estel, B. A., Jacob, C. O., Kamen, D. L., Gilkeson, G. S., Brown, E. E., Alarcon, G. S., Edberg, J. C., Kimberly, R. P., Martin, J., Merrill, J., Harley, J. B., Kaufman, K. M., Reveille, J. D., Anaya, J. M., Criswell, L. A., Vila, L. M., Petri, M., Ramsey-Goldman, R., Bae, S. C., Boackle, S. A., Vyse, T. J., Niewold, T. B., Cohen, P., Powell, D. W. (2013). ABIN1 dysfunction as a genetic basis for lupus nephritis. Journal of the American Society of Nephrology : JASN, 24(11), 1743-54. PMID: 23970121. DOI: 10.1681/ASN.2013020148

Chaudhry, M. A.*, Scofield, R. H.# (2013). Atypical Rocky Mountain spotted fever with polyarticular arthritis. The American journal of the medical sciences, 346(5), 427-9. PMID: 24157965. DOI: 10.1097/MAJ.0b013e318295c788

Lessard, C. J., Li, H., Adrianto, I., Ice, J. A., Rasmussen, A., Grundahl, K. M., Kelly, J. A., Dozmorov, M. G., Miceli-Richard, C., Bowman, S., Lester, S., Eriksson, P., Eloranta, M. L., Brun, J. G., Gøransson, L. G., Harboe, E., Guthridge, J. M., Kaufman, K. M., Kvarnström, M., Jazebi, H., Cunninghame Graham, D. S., Grandits, M. E., Nazmul-Hossain, A. N., Patel, K., Adler, A. J., Maier-Moore, J. S., Farris, A. D., Brennan, M. T., Lessard, J. A., Chodosh, J., Gopalakrishnan, R., Hefner, K. S., Houston, G. D., Huang, A. J., Hughes, P. J., Lewis, D. M., Radfar, L., Rohrer, M. D., Stone, D. U., Wren, J. D., Vyse, T. J., Gaffney, P. M., James, J. A., Omdal, R., Wahren-Herlenius, M., Illei, G. G., Witte, T., Jonsson, R., Rischmueller, M., Rönnblom, L., Nordmark, G., Ng, W. F., Mariette, X., Anaya, J. M., Rhodus, N. L., Segal, B. M., Scofield, R. H., Montgomery, C. G., Harley, J. B., Sivils, K. L. (2013). Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nature genetics, 45(11), 1284-92. PMID: 24097067. DOI: 10.1038/ng.2792

Namjou, B., Kim-Howard, X., Sun, C., Adler, A., Chung, S. A., Kaufman, K. M., Kelly, J. A., Glenn, S. B., Guthridge, J. M., Scofield, R. H., Kimberly, R. P., Brown, E. E., Alarcón, G. S., Edberg, J. C., Kim, J. H., Choi, J., Ramsey-Goldman, R., Petri, M. A., Reveille, J. D., Vilá, L. M., Boackle, S. A., Freedman, B. I., Tsao, B. P., Langefeld, C. D., Vyse, T. J., Jacob, C. O., Pons-Estel, B., Niewold, T. B., Moser Sivils, K. L., Merrill, J., Anaya, J. M., Gilkeson, G. S., Gaffney, P. M., Bae, S. C., Alarcón-Riquelme, M. E., Harley, J. B., Criswell, L. A., James, J. A., Nath, S. K. (2013). PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PloS one, 8(8), e69404. PMID: 23950893. DOI: 10.1371/journal.pone.0069404

Maier-Moore, J. S.*, Cañas, C. A., Tobón, G., Arango, A., Anaya, J. M.*, Scofield, R. H.# (2013). The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians. Clinical immunology (Orlando, Fla.), 148(2), 206-8. PMID: 23773920. DOI: 10.1016/j.clim.2013.05.010

Igoe, A.*, Scofield, R. H.# (2013). Autoimmunity and infection in Sjögren's syndrome. Current opinion in rheumatology, 25(4), 480-7. PMID: 23719365. DOI: 10.1097/BOR.0b013e32836200d2

Kurien, B. T., Dsouza, A., Igoe, A.*, Lee, Y. J., Maier-Moore, J. S.*, Gordon, T., Jackson, M., Scofield, R. H.# (2013). Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice. Clinical and experimental immunology, 173(1), 67-75. PMID: 23607771. DOI: 10.1111/cei.12094

Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Brown EE, Petri M, Ramsey-Goldman R, Reveillw JD, James JA, Guthridge J, Merill JT, Boackle SA, Freedamn BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Segovia ME, Harley JB, Gilkeson GS. Association of reactive intermediate genes with systemic lupus erythematosus (SLE) varies across populations with different African ancestries. J Rheumatol 40:842-849, 2013 Jun

Kurien BT, D’souza  A, Igoe A, Le YJ, Maier-Moore  J, Gordon TP, Jackson M, Scofield RH. Immunization with 60 kD Ro peptide produces different stages of pre-clinical autoimmunity in a Sjögren’s syndrome-model among multiple strains of inbred mice. Clin Exp Immunol 173:842-849, 2013 May

Maier-Moore JS, Cañas CA, Tobón G, Anaya, J-M, Scofield RH.  The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians. Clin Immunol 148:206-208, 2013 May

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcón GS, Vyse TJ, Pons-Estel BA; Argentine Collaborative Group, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarc?n-Riquelme ME; BIOLUPUS and GENLES networks, Brown EE, Tsao BP. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.  PLoS Genet. 9(2):e1003336, 2013.   (PMCID:PMC3585142)

Aggarwal R, Dillon SP, Sestak AL, Chakravarty EF, Harley JB, Scofield RH. Excess female siblings and male fetal loss in lupus families. J Rheumatol 40:430-434, 2013 Apr

Molineros JE, Maiti AK, Sun C, Looger LL, Kim-Howard X, Glenn S, Adler A, Han S, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Graciela S. Alarcón GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcón-Riquelme ME on behalf of the BIOLUPUS Network, Williams SM, Merrill JT, James JA, Kenneth M. Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture Mapping in Systemic Lupus Erythematosus (SLE) Identifies Multiple Common Functional Variants within IFIH1 Associated with Apoptosis, Inflammation and Autoantibody Production  PloS Genetics 9:e1003222, 2013 Feb. (PMCID:PMC3575474)

Kim K, Brown EE, Choi C-B, Alarcón-Riquelme ME on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Bang S-Y, Lee H-S, Boackle SA, Criswell LA, Kim T, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya J-M, Guthridge JM, Nath SK, Richardson B, Sawalha AH, Kang YM, Shim SC, Suh C-H, Lee S-K, Kim C-S, Merrill JT, Petri M, Ramsey-Goldman R Vilá LM, Niewold TB, Martin J, Pons-Estel BA on behalf of GENLES, Vyse TJ, Freedman BI, Moser KL Gaffney PM, Williams A, Comeau M, Reveille JD, James JA, Scofield RH, Langefeld, CD, Kaufman KM, Harley JB, Kang C, Kimberly RP, Bae S-C. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestry populations. Ann Rheum Dis 71:1809-1814, 2012. (PMCID:PMC3466387)

Namjou B, Keddache M, Fletcher D, Dillon S, Kottyan L,  Wiley G , Gaffney PM, Wakeland BE, Liang C, Wakeland EK, Scofield RH, Kaufman KM, Harley JB. Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency. Lupus 21:1113-1118. Epub 2012 Apr 3. (PMCID:PMC3508769)

Lu R, Robertson J, Bruner B, Guthridge JM, Neas B, Nath SK, Kelly JA, Moser KL, Chakravarty E, Kamen D, Gilkeson GS, Scofield RH, Harley JB, James JA. Multiple autoantibodies display association with lymphopenia, proteinuria, and cellular casts in a large, ethnically diverse SLE patient cohort.  Autoimmune Dis 2012:819634, 2012. Epub 2012 Sep 4. (PMCID:PMC3439936)

Bruner BF, Gutherridge JM, Lu R, Vidal G, Kelly JA, Robertson JM, Kamen DL, Gilkeson GS, Neas BR, Reichlin M, Scofield RH, Harley JB, James JA. Comparison of autoantibody specificities and clustering between traditional and bead-based autoantibody assays in a large, ethnically diverse collection of SLE patients and family members.  Arthritis Rheum 64:3677-3686, Nov 2012 (PMCID:PMC3490432)

Gaddy JR, Khan ZZ, Chaser B, Scofield RH.  Whipple's disease diagnosis following the use of TNF-? blockade. Rheumatol (Oxford) 51:946, 2012 (No PMCID required)

Sánchez  E, Rasmussen A, Riba L, Acevedo E, Kelly JA, Langefeld CD, Williams AH, Ziegler JT, Comeau ME, Marion MC, IGarcía-De La Torre I, Maradiaga-Ceceña MA, Cardiel  MH, Esquivel-Valerio JA, Rodriguez-Amado J, Moctezuma JF, Miranda P, Perandones C, Castel C, Laborde HA,  Alba P, Musuruana J, Goecke A, Foster C, Anaya JM, Kaufman KM, Adler  AJ, Glenn SB, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Vilá LM, Criswell LA, Gilkeson GS, Niewold TB, Martin J, Vyse TJ, Boackle SA, Ramsey-Goldman R, Stevens AM, Scofield RH, Petri M, Merrill JT, Reveille JD, Tsao BP, Orozco L, Baca V, Moser KL, Gaffney PM, James JA, Harley JB, Tusié-Luna T, Pons-Estel BA, Jacob CO, Alarcón-Riquelme ME. Impact of Genetic Ancestry and Socio-Demographic Status on the Clinical Expression of Systemic Lupus Erythematosus in Amerindian-European Populations, Arthritis Rheum 64:3687-3694, Nov 2012 (PMCID:PMC3485439)

Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martín J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.  Arthritis Rheum 64:3695-3705, Nov 2012 PMCID:PMC3485412)

Namjou B, Choi C-B, Isaac T. W. Harley ITW, Kim K, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcón-Riquelme ME, Caroline J. Gallant CJ, Susan A. Boackle SA, Criswell LA, Kimberly RP, Brown E, Edberg J, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Kim E-M, Guthridge J, Merrill JT, Petri M, Ramsey-Goldman R, Vila L, Niewold TB, Martin J, Pons-Estel BA,  Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams A Comeau, Reveille JD, Kang C, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Bae S-C. Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis Rheum 64:1960-1969, 2012. (PMCID:PMC3380425)

Kurien BT, D’Souza, A, Terzyan S, Scofield RH. Putative sequences on Ro60 three-dimensional structure accessible for 4-hydroxy-2-nonenal (HNE) modification compared to in vitro HNE modification of Ro60 sequences.  Mol Immunol 50:185-192, 2012

Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya J-M, Alarcón-Riquelme ME on behalf of the BIOLUPUS and GENLES Networks, Martin J, Glenn S, Adler A, Bae S-C, Park S-Y, Boackle SA, Brown EB, Edberg JC, Alarcón GS, Petri M, Criswell LA, Ramsey-Goldman R, Reveille JD, Vila LM, Gilkeson GS, Kamen DL, Ziegler J, Jacob CO, Rasmussen A, James JA, Kimberly RP, Merrill JT, Niewold, TB, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Moser KL, Harley JB, Gaffney PM, Montgomery CG. Role of MYH9 and APOL1 in African and non-African populations with Lupus Nephritis.  Gene Immunity 13:232-238, 2012. (PMCID:PMC3330160

Dillon SP, Kurien BT, Li S, Bruner GR, Kaufman KM, Harley JB, Gaffney PM, Wallace DJ, Weisman MH, Scofield RH. Sex chromosome Aneuploides among Men with Systemic Lupus Erythematosus, J Autoimmun 38:J129-J134, 2012.  Epub ahead of print 5 Dec 2011 PMCID:PMC3309073)

Scofield AK, Radfar L, Ice J, Houston GD, Lewis D, Moser KL, Scofield RH.  Peripheral Neuropathy in Sjögren’s Syndrome. J Clin Rheumatol 18:290-293, 2012. (NIHMSID #442761)

Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarón-Riquelme ME on behalf of the BIOLUPUS and GENLES Networks, Alarcón GS, Anaya J-M, Bae S-C, Kim J-H, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD,Harley JB, Wakeland EK, Moser KL, Montgomery, CG, Gaffney PM. A functional haplotype of UBE2L3 confers risk for Systemic 1 Lupus Erythematosus. Genes Immun 13:380-3807, 2012.  Epub 2012 Apr 5. (PMCID:PMC3411915)

Sawalha AH, Wang L, Nadig A, Somers E, McCune J on behalf of the Michigan Lupus Group, Hughes T, Merrill J, Scofield RH, Strickland. F. Richardson B. Gender-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity.  J Autoimmun 38:J216-222, 2012. Epub 2012 Feb 3. (PMCID:PMC3313010)

Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcón GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vilá LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcón-Riquelme ME; BIOLUPUS Network, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-699, 2012. Epublished ahead of print 2011 Nov 21. (PMCID:PMC3324666)

Kaufman KM, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, James JA, Guthridge, J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Brown EB, Vilá LM, Anaya J-M, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Jacob CO, Scofield RH, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Niewold TB, Vyse TJ, Bae, S-C, Alarcón-Riquelme ME on behalf of the BIOLUPUS network, Harley JB, Sawalha AH,  Betty P. Tsao BP. Fine mapping of Xq28: Both MECP2/IRAK1 and NAA10/RENBP contribute to risk for systemic lupus erythematosus in multiple ancestral groups.  Ann Rheum Dis 72:437-444, 2013 Mar (PMCID:PMC3567234)

Hughes T, Adler A, Kelly JA, Kaufman KM, Williams AH, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martín J, Niewold TB, Vilá LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcón-Riquelme ME; BIOLUPUS Network, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.  Arthritis Rheum 64:485-492, 2012. (PMCID:PMC3268866)

Kurien BT, Dorri Y, Bachmann M, Scofield, RH. Induction of anti-Ro60/anti-La by immunization with spectrin and, induction of anti-spectrin by immunization with Ro60 and 4-hydroxy-2-nonenal-modified Ro60 immunization. Clin Exp Rheumatol 30:886-893, Nov-Dec 2012.

Lessard CJ, Adrianto I, Kelly JA, Kaufman KM, Grundahl KM, Adler A, Williams AH, Gallant C, Alarcón-Riquelme ME for the BIOLUPUS and GENLES Networks, Anaya J-M, Bae S-C, Boackle SA, Brown EE, Chang D-M, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park S-Y, Petri MA, Pons-Estel BA, Rosalind Ramsey-Goldman R, Reveille JD, Song YW, Stevens AM,  Tsao BP, Vila LM, Vyse TJ, Yu C-Y, Guthridge JM, Bruner GR, Langefeld CD, Montgomery C, Harley JB, Scofield RH, Gaffney PM, Moser KL. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multi-ethnic study. Am J Hum Genet 88:83-91, 2011 (PMCID:PMC3014359)

Zhao J, Wu H, Khosravi M, Huijuan Cui H, Qian X, Kelly JA, Kaufman KM, Langefeld CD, Williams AH, Comeau ME, Julie T. Ziegler JT, Marion MC, Adam Adler A, Glenn SB, Alarcón-Riquelme ME on behalf of the BIOLUPUS and GENLES networks, Harley JB, Bae S-C, Lee JH, J-S Lee, Jacob CO, Timothy J. Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, James JA, Gilkeson, Kamen DL, Freedman BI, Anaya J-M, Merrill JT, Criswell LA, Scofield RH, Stevens AM, Boackle SA, Guthridge JM, Chang D-M, Song YW, Grossman JM, Hahn BH, Goodship THJ, Cantor RM, Yu C-Y, Shen N, Tsao BP. Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility. PloS Genetics  7:e1002079, 2011 (PMCID:PMC3102741)

Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcon-Riquelme ME for the BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nature Genet 43:253-258, 2011. (PMCID: PMC3103780)

Kurien BT, Porter A, Dorri Y, Iqbal S, D'Souza A, Singh A, Asfa S, Cartellieri M, Mathias K, Matsumoto H, Bachmann M, Hensley K, Scofield RH. Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal differentially induces Sjogren's syndrome or systemic lupus erythematosus in BALB/c mice. Free Radical Biol Med 50:1222-1233, 2011 (NIHMS245498).

Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Bae S-C,  Lee JH, Lee J-S, Chang D-M, Song YW, Yu C-Y, Robert P. Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, Alarcón-Riquelme ME on behalf of the BIOLUPUS and GENLES networks, Harley JB, Boackle SA, Stevens AM, Scofield RH, Merrill JT, Freedman BI, Anaya, J-M, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups.  Arthritis Rheum 63:2755-2763, 2011(PMCID: PMC3163110)

Bippes CC, Feldmann A, Stamova S, Cartellieri M, Schwarzer A, Wehner R, Schmitz M, Riber EP, Zhao S, Schäkel K, Temme A, Scofield RH, Kurien BT, Bartsch H, Bachmann M. A Novel Modular Antigen Delivery System for Immunotargeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs). PLoS One 21:e16315, 2011 (PMCID:PMC3025022)

Rasmussen A, Sevier S, Kelly J, Glenn S, Aberle T, Cooney CM, Grether A, Goodmon E, Ning J, Tesiram J, Morrisey J, Powe T, Drexel M, Daniel W, Namjou B, Ojwang JO, Nguyen KM,  Cavett JW, Te JL, James JA, Scofield RH, Moser KL, Gilkeson GS, Kamen DL, Carson C, Ballesteros MdC, Punaro MG, Quintero-del-Rio AL, Karp DR, Wallace DJ, Weisman M, Merrill J, Rivera R, Petri MA, Albert DA, Espinoza LR, Utset TO, Shaver TS, Arthur E, Anaya JM, Bruner GR, Harley JB. The Lupus Family Registry and Repository. Rheumatol 50:47-59, 2011 (PMCID:PMC3307518)

Dillon S, Aggarwal R, Harding JW Jr, Li L-J, Weissman MH, Li S, Cavett JW, Sevier ST,  Ojwang JW, D’Souza A, Harley JB, Scofield RH. Klinefelter’s syndrome (47,XXY) among men with systemic lupus erythematosus. Acta Paediatrica 100:819-823, 2011

Rittenhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC, Dedeke AB, . Harley JB, Scofield RH, Guthridge JM, James JA. Extended report: Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 70:1569-1574, 2011. (Published Online First: 17 May 2011) (reviewed and recommended by Faculty of 1000) (PMCID:PMC3149865)

Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcón-Riquelme ME, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown E, Edberg J, Stevens AM, Jacob CO, Tsao BP, Gilkeson GS, Kamen DL, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Anaya J-M, Niewold TB, Martin J, Pons-Estel BA, Sabio JM, Callejas JL, Vyse TJ, Bae S-C, Perrino FW, Freedman BI, Scofield RH, Moser KL, Gaffney PM, James JA, Langefeld CD, Kaufman KM, Harley JB, Atkinson JP. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immunity  12:270-279, 2011. (PMCID:PMC3107387)

Lee YJ, Scofield RH, Hyon JY, Yun P-Y. Lee H-J, Lee EY, Lee EB, Song YW.  Salavary chemokine levels in patients with Sjögren’s syndrome. Rheumatol 49:1747-1752, 2010 (PMCID:PMC2919196)

Dorri Y, Kurien BT, Scofield RH. Problems with multiple use of transfer buffer in protein electrophoresis transfer. J Biomol Tech 21:1-2, 2010 (PMCID:PMC2841995)

Cooney CM, Bruner GR, Aberle T, Namjou-Khales B, Myers LK, Feo L, Li S, D'Souza A, Ramirez A, Harley JB, Scofield RH. 46,X,del(X)(q13) Turner's syndrome women with systemic lupus erythematosus in a pedigree multiplex for SLE. Genes Immun. 10:478-481, 2009. Epub 2009 May 21. (PMCID:PMC2722751)

Canzler U, Bartsch H, Kurien BT, James JA, Scofield RH, Grossmann K, Lehmann W, Pillarsky C, Denz A, Grützmann R, Conrad K, Schmitz M, Rieber EP, Distler W, Bachmann MP Detection of autoantibodies to tumor-associated antigens in sera of patients with systemic autoimmunity using a novel protein microblot array. Scand J Immunol 69:563-569, 2009.

Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Jacob N, Ciobanu V, Kaufman KM, Kelly JA, Ojwang JO, Quismorio F, Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR, Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D, Wagner-Weiner D, Nocton J, Putterman C,  Bae S-C, Kimberly RP, Vyse TJ, Gilkeson GS, Kamen D, Alarcón-Riquelme ME, Langefeld CD, Gaffney PM, Moser KL, Merrill JT, Scofield RH, James JA, Harley JB, Jacob CO. Robust Association of STAT4 with Systemic Lupus Erythematosus in Four Different Racial Groups. Arthritis Rheum 60:1085-1095, 2009. PMCID #2776081.

Gomez-Mejiba SE, Pye Q, Kurien BT, Akram H, Zhai Z, Hensley M, Scofield RH, Ramirez DC. Inhalation of Environmental Stressors & Chronic Inflammation: Autoimmunity and Neurodegeneration. Mutat Res 674:62-72, 2009. PMCID:PMC2676865.

Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefield CD, Marion MC, Williams AH, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldberg R, Reveille JD, McGwin G, Vila LM, Petri MA, Vyse TJ, Merrill JT, Gregersen PK, James JA, Nath SW, Harley JB, Guthridge JM. Replication of the BANK1 genetic association with systemic erythematosus in a European-derived popoulation. Gene Immunity 10:531-538, 2009 NIHMSID:124437.

Kurien BT, Scofield RH, eds., Methods in Molecular Biology: Protein Blotting and Detection (Human Press: London), volume 536, 2009.

Scofield RH, Nguyen TT. Milk-alkali syndrome. In, Pourmotabbed G, Talavera F, Khardori R, Cooper M, Griffing GT, eds, Medicine Specialties: Endocrinology (emedicine.com), 2009.

Kurien BT, Scofield RH. Oral administration of heat-solubilized curcumin for potentially increasing curcumin bioavailability in experimental animals.  Int J Cancer. 2009 Apr 27.

Selby GB, Mosallaei_Benjamin M, Kalyanaraman V, Lancaster A, Scofield RH. Difficulties in monitoring the glucose status of patients undergoing hematopoietic stem cell transplantation.  Biol Blood Marrow Transplant. 15:1000, 2009.

Kurien BT, Scofield RH. Curry spice curcumin and prostate cancer. Mol Nutr Food Res. 53:939-940, 2009.

Kurien BT, Scofield RH. Increasing aqueous solubility of curcumin for improving bioavailability. Trends Pharmacol Sci. 30:334-335, 2009. Epub 2009 Jun 10.

Sawalha AH, Harley JB, Scofield RH. Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes.  J Autoimmun. 33:31-34, 2009. Epub 2009 May 22.

Kurien BT, Scofield RH. Bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants. Med Hypotheses. 73:462-463, 2009. Epub 2009 May 10.

Kurien BT, Scofield RH. Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification. Mol Nutr Food Res. 53:308, 2009.

Kurien BT, Scofield RH. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 15:747, 2009.

Dillion SP, D’Sousa A, Kurien BT, Scofield RH. Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serum. Biotechnol J. in press, Epub 2009 Apr 15.

Scofield RH. Genetics of Systemic Lupus Erythematosus and Sjögren’s Syndrome. Curr Opin Rheum 21:448-453, 2009.

Namjou B, Scofield R, Kelly J, Goodmon E, Aberle T, Bruner G, Harley J. The effects of previous hysterectomy on lupus.  Lupus. 2009;18:1000-1005, 2009.

Scofield RH, Oates JC. The place of William Osler in the description of systemic lupus erythematosus. Am J Med Sci, 338:409-412, 2009. NIHMSID:126882.

Aggarwal R, Sestak AL, Namjou B, Scofield RH. Complement deficiency in a large cohort of familial systemic lupus erythematosus.  Lupus, in press.

Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Hervé M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Rai KR, Chu CC, Chiorazzi N. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and chemical oxidation. Mol Med, in press.

Bruner GR, Cooney CM, Harley JB, Scofield RH. 46,XX del (Xq) Turner Syndrome Female with Systemic Lupus Erythematosus in a Pedigree Multiplex for SLE. Arthritis Rheum, revisions requested and submitted.

Kurien BT, Scofield RH. Lipstick consumption and systemic lupus erythematosus: Nothing to gloss over, Clin Rheumatol 27:1339-40, 2008.

Kurien BT, Scofield RH. Hydroxy-nonenel oxidative modification of proteins in systemic lupus. Rheumatol. 47:1587, 2008.

Scofield RH, Bruner GR, Kelly J, Harley JB. Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 58:2511_2517, 2008.

Kamen DL, Shaftman SR, Barron M, Parker TM, Bruner GR, Aberle T, James JA, Scofield RH, Harley JB, Gilkeson GS, Autoantibody Prevalence and Lupus Disease Characteristics in a Unique African American Population. Arthritis Rheum 58:1237-1247, 2008.

Kurein BT, D’sousa A, Rodgers R, Shenoi J, Kurono S, Matsumoto H, Asfa S, Hensley K, Scofield RH. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the association of a polymorphism in its promoter region as a risk factor in SLE. BMC Med Genet 9:62, 2008. (PMID:18606005).

Sawalha AH, Webb R, Han S, Kelly JA, Kaufman KM, Kimberly RP, Alarcón-Riquelme ME, James JA, Vyse TJ,  Gilkeson G, Choi C-B, Scofield RH, Bae S-C, Nath SK, Harley JB. Common variants within MECP2 confer risk of systemic lupus erythematosus. PloS ONE 5;3:e1727, 2008 (PMID: 18320046).

Mathews SA, Kurien BT, Scofield RH. Oral manifestations of Sjögren’s syndrome. J Dent Res 87:308-318, 2008 (PMID: 18362310).

Scofield RH. Autoimmune hypo- and hyperthyroid  in systemic autoimmune disease. In, Walker SE, Jara LJ, eds, Handbook of Systemic Autoimmune Diseases 9:195-205, 2008.

Kurien BT, Scofield RH.  Autoimmune diseases and oxidatively modified autoantigens Autoimmunity Rev 7:567-573, 2008. Epub 2008 May 27.

Malik S, Bruner GR , Williams-Weese C, Feo L, Scofield RH, Reichlin M, Harley JB, Sawalha AH.  The presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients.  Lupus 16:863-866, 2007 (PMID: 17971358).

Pham T, Pesina J, Scofield RH. 13-cis-retinoic acid induction of clinical polycystic ovarian disease. Endocr Prac 13:776-779, 2007 (PMID: 18194936).

Tauseef A, Greenfield RA, Scofield RH, Bronze MS. Gatifloxacin –Associated Hypoglycemia.  J Okla St Med Assoc 100:425-428, 2007.

Williams PH, Cobb BL, Namjou B, Scofield RH, Sawalha AH, Harley JB. Horizons in Sjögren's Syndrome Genetics. Clin Rev Allergy Immunol 32:201-209, 2007 (Epub ahead of print 26 Oct 2007) (PMID: 17963047).

Blevins S, Leyva, MJ, Wright JE, Scofield RH, Aston CE. Effect of Cinnamon on Glucose and Lipid Levels in Non-insulin Dependent Type 2 Diabetes Mellitus. Diabetes Care 30:2236-2237, 2007 (PMID: 17563345).

Kamble S, Kem D, Baker MZ, Scofield H, Lyons T, Olansky L. Thymic neuroendocrine tumor presenting as Cushing’s syndrome: A case report and review of current literature. EndoTrends 14:10-11, 2007. 

Pham T, Cornea A, Blick KE, Jenkins A, Scofield RH. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 333:333-339, 2007 (PMID 17570985).

Kurien BT, Scofield RH. Four men in a space station - to say nothing of the cow!: the quest for finding respite and work in the ultimate frontier. Med Hypotheses 68:1195-1199, 2007 (PMID: 17306929).

Kurien BT, Singh A, Matsumoto H, Scofield RH. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol. 5:567-576, 2007 (PMID: 17767425).

Kurien BT, Mathews SA, Scofield RH. Can low dose diagnostic dental radiation trigger Sjögren's syndrome? Medical Hypotheses 69:995-1000, 2007  (Epub 2007 Apr 17) (PMID: 17442501) .

Scofield RH, Bruner GR, Harley JB, Namjou B. Autoimmune thyroid disease is associated with secondary Sjögren’s syndrome in familial systemic lupus. Ann Rheum Dis 66:41-413, 2007 (Epub August 24, 2006 at http://ard.bmjjournals.com).

Addington S, Larsen N, Scofield RH. Milk-alkali syndrome in pre-eclamptic pregnancy. J Okla St Med Assoc 99:480-484, 2006.

Scofield RH. Poor, Poor Thing. Blood and Thunder: Musing on the Art of Medicine. 6:106-108, 2006.

Wang, H., Kurien, B.T., Lundgreen, D., Patel, N.C., Kaufman, K.M., Miller, D.S., Porter, A.C., D’Sousa, A., Nye, L., Tumbush, J., Kerr, D.S., Kurono, S., Matsumoto, H., Scofield, R.H.  A Nonsense Mutation Of PEPD In Four Amish Children With Prolidase Deficiency.  Am J Med Genet 140:580-5, 2006.

Poole BD, Scofield RH, Harley JB, James JA.  Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus.  Autoimmunity 39:63-70, 2006.

Kurien, B.T., Patel, N.C., Porter, A.C., Miller, D., D’Sousa, A., Matsimoto, H., Heng, W., Scofield, R.H.   Prolidase Deficiency and Biochemical Assays Used In Its Diagnosis. Anal Biochem, revisions requested.

Beall DP, Henslee HB, Webb HR, Scofield RH.  Milk-alkali syndrome: a historical review and description of the modern version of the syndrome.  Am J Med Sci. 331:233-42, 2006.

Kurien BT, Singh A, Matsumoto H, Scofield RH. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol. 5:567-576, 2007 (PMID: 17767425).

Kurien BT, Scofield RH. Lipid peroxidation in SLE.  Indian J Exp Biol 44:349-356, 2006. (PMID: 16708886).

Kurien BT, Patel NC, Porter AC, Miller D, D’Sousa A, Matsimoto H, Wang H, Scofield RH. Proidase deficiency and biochemical assays used in its diagnosis. Anal Biochem 349:165-175, 2006 (PMID: 16298326).

Kurien BT, Scofield RH. Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol 64:227-235, 2006 (PMID: 16918691).

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Reviews and Invited Papers

Igoe A, Scofield RH. Autoimmunity and Infection in Sjogren's Syndrome.  Curr Op Rheumatol 25:480-487, 2013 Jul

Kurien BT, Scofield RH.  Autoimmune diseases and oxidatively modified autoantigens Autoimmunity Rev, in press.

Scofield RH. Viewpoints in Genetic Medicine: Can Genetic Changes Predict Manifestations of SLE? In, Beuhler B, ed. Medscape Genomic Medicine, 2011 (no PMCID required)

Scofield RH. Vasculitis in Sjögren's Syndrome. Curr Rheumatol Rep 13:482-488, 2011 (No PMCID required)

Scofield RH.  Can Genetic Changes Predict Manifestations of SLE. Viewpoints in Genomic Medicine, in Medscape Genomic Medicine, May 2011 (No PMCID required) (http://www.medscape.com/viewarticle/742165)

Scofield RH. IL-21 and Sjögren’s syndrome. Arthritis Res Ther 13:137, 2011 (PMCID: PMC3334639)

Scofield RH. Do we need new autoantibodies in lupus? Arthritis Res Therapy. 12:120, 2010 (PMCID:PMC2911855)

Mathews SA, Kurien BT, Scofield RH. Oral manifestations of Sjögren’s syndrome. J Dent Res 87:308-318, 2008.

Scofield RH. Autoimmune hypo- and hyperthyroid  in systemic autoimmune disease. In, Walker SE, Jara LJ, eds, Handbook of Systemic Autoimmune Diseases 9:195-205, 2008.

Williams PH, Cobb BL, Namjou B, Scofield RH, Sawalha AH, Harley JB. Horizons in Sjögren's Syndrome Genetics. Clin Rev Allergy Immunol 32:201-209, 2007 (Epub ahead of print 26 Oct 2007) (PMID: 17963047).

Kurien BT, Scofield RH. Western Blotting. Methods 38:283-293, 2006. (PMID: 16483794).

Kurien BT, Hensley K, Bachmann M, Scofield RH. Oxidatively modified autoantigens in autoimmune diseases. Free Rad Biol Med 41:549-556, 2006.

James JA, Harley JB, Scofield RH. Epstein Barr virus and Systemic Lupus Erythematosus. Curr Opin Rheumatol 18:462-467, 2006.

Kurien BT, Scofield RH. Lipid peroxidation in SLE.  Indian J Exp Biol 44:349-356, 2006.

Kurien BT, Patel NC, Porter AC, Miller D, D’Sousa A, Matsimoto H, Wang H, Scofield RH. Proidase deficiency and biochemical assays used in its diagnosis. Anal Biochem 349:165-175, 2006.

Kurien BT, Scofield RH. Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol 64:227-235, 2006.

Beall DP, Henslee HB, Webb HR, Scofield RH. Milk alkali syndrome: Historical review and description of the modern version of the syndrome. Am J Med Sci 331:233-242, (PMID: 16702792) 2006.

Poole BD, Scofield RH, Harley JB, James JA. Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autommunity  39:1-8, 2006.

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Books Chapters and Manuscripts

Kurien, B. T., Scofield, R. H. (2015). Detection of blotted proteins: Methods and Protocols. Methods in Molecular Biology Series (vol. 1314). New York, NY: Humana Press/Springer Science

Scofield, R. H. (2014). Ro/SSA Autoantibodies. The Autoantibodies (pp. 233-238). New York): Elsevier, Shoenfeld Y, Meroni PL, and Gershwin ME., eds

Scofield, R. H. (2013). Mechanisms of Tissue Damage - Free radicals and fibrosis,. Lupus Erythematosus and Related Syndromes (pp. 175-190). Philadelphia: Elsevier

Lessard CJ, Ice JA, Maier-Moore S, Montgomery CG, Scofield RH, Kathy L. Moser KL. Genetics, Genomics, and Proteomics of Sjögren’s syndrome. In, Ramos-Casals M, Stone JH, Moutsopoulos HM, eds, Sjögren’s Syndrome: Diagnosis and Therapeutics, 11-32, 2012. (No PMCID required)

Kurien BT, Mohan C, Scofield RH. Mechanisms of Tissue Damage - Free radicals and fibrosis, In, Wallace DJ, Hahn BH, eds, Dubois’ Lupus Erythematosus and Related Syndromes (Elsevier:Philadelphia), pp 175-190, 2013 (No PMCID required)

Scofield RH. Ro/SSA Autoantibodies. In, eds, Vehuda Shoenfeld, M Eric Gershwin, and Pier Luigi Meroni. The Autoantibodies (Elsevier:New York), 2013, in press (No PMCID required)

Scofield RH, Kaufman KM. Mapping Susceptibility Gene in Systemic Lupus Erythematosus. In, Perl A, ed, Autoimmunity: Methods and Protocols, Methods in Molecular Biology 900:11-15, 2012 (No PMCID required)

Kurien BT, Scofield RH, eds. Protein electrophoresis: Methods and Protocols. Humana Press: New York, 2012 (No PMCID required)

Kurien BT, Scofield RH, eds., Methods in Molecular Biology: Protein Blotting and Detection (Human Press: London), volume 536, 2009.

Scofield RH, Nguyen TT. Milk-alkali syndrome. In, Pourmotabbed G, Talavera F, Khardori R, Cooper M, Griffing GT,eds, Medicine Specialties: Endocrinology (emedicine.com), 2009.

Zacharias L, Scofield RH. Rheumatic Manifestations of Systemic Disease. In, Lohr KM, Talavera F, Brent LH, Plantz SH, Zevitz ME, eds, Textbook of Medicine (emedicine.com),
2006.

Reichlin, M, Scofield, RH. Ro (SS-A) antibodies. In: Shoenfeld Y, Gershwin ME, and Meroni PL, eds, Textbook of Autoantibodies, 2nd ed, (Elsevier:Amsterdam), 2006.

Scofield RH. Milk-alkali syndrome. In, Pourmotabbed G, Talavera F, Khardori R, Cooper M, Griffing GT, eds, Medicine Specialties: Endocrinology (emedicine.com), 2006.

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