Ping Song, PhD Assistant Professor of Research
Mailing Address: 941 Stanton L. Young Blvd., BSEB 315 Oklahoma City, OK 73104	Telephone: (405) 271-5896 ext 48496 Fax: (405) 271-3973
Email: ping-song@ouhsc.edu

Research Interests

1. The roles of tumor suppressors in vessel remodeling.
2. Insulin resistance: focus on the role of reactive nitrogen species in insulin signal transduction.
3. Thromboxane A2 receptor-mediated antiangiogensis.

Education

Xu J, Wang S, Wu Y, Song P, and Zou MH. Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice with Angiotensin II-induced Hypertension. Hypertension, (in press), 2009.

Wang S, Xu J, Song P, Viollet B, and Zou MH. In Vivo Activation of AMP-activated Protein Kinase Attenuates Diabetes-enhanced Degradation of GTP Cyclohydrolase I. Diabetes, 58: 1893-1901, 2009.

Song P, Zhang M, Wang S, Xu J, Choi HC, and Zou MH. Thromboxane A2 Receptor Activates a Rho-associated Kinase/LKB1/PTEN Pathway to Attenuates Endothelium Insulin Signaling. J Bio Chem, 284(25): 17120-17128, 2009.

Wang S, Xu J, Song P, Wu Y, Zhang J, Choi HC, and Zou MH. Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure. Hypertension, 52: 484-490, 2008.

Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons TJ, and Zou MH. Activation of Protease Calpain by Oxidized and Glycated LDL Increases the Degradation of Endothelial Nitric Oxide Synthase. J. Cell. Mol. Med, 12(5): 1-12, 2008.

Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, and Zou MH. Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statin in Vivo. J  Biol Chem, 283(29): 20186-20197, 2008.

Song P, Xie Z, Wu Y, Xu J, Dong Y, and Zou MH. Protein Kinase C ζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells. J  Biol Chem, 283(18): 12446-12455, 2008.

Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, and Zou MH. Thromboxane Receptor Activates the AMP-Activated Protein Kinase in Vascular Smooth Muscle Cells via Hydrogen Peroxide. Circ Res, 102(3): 328-337, 2008.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, and Zou MH. Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in a LKB1-Dependent Manner. Circulation. 116:1585-1595, 2007.

An Z*, Wang H*, Song, P. *, Zhang M, Geng X, and Zou MH. Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes: A Role for Oxidant Stress. J Biol Chem. 282(37): 26793-26801, 2007. (*Joint first authors).

Xu J, Wu Y, Song P, Zhang M, Wang S, and Zou MH. Proteasome-dependent Degradation of Guanosine 5’-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus. Circulation. 116(8):944-953, 2007.

Wu Y, Song P, Xu J, Zhang M, and Zou MH. Activation of Protein Phosphatase 2A by Palmitate Inhibits AMP-activated Protein Kinase. J Biol Chem. 282(13):9777-9788, 2007.

Song P, Wei J-X, and Wang HCR. Distinct roles of the ERK pathway in modulating apoptosis in Ras-transformed and non-transformed cells induced by anticancer agent FR901228. FEBS Letters, 579(1): 90-94, 2005.