Brenda Smith, PhD Adjunct Associate Professor
Mailing Address: PO Box 26901, WP 2140 Oklahoma City, OK 73190	Telephone: (405) 271-2601 Fax: (405) 271-1194
Email: brenda-smith@ouhsc.edu

Research Interests

1. The immune and antioxidant systems play an integral role in the regulation of bone cell metabolism and consequently skeletal integrity.  The focus of our research is to understand the mechanisms by which inflammatory mediators alter oxidative status and the calcium regulatory system resulting in the dysregulation of bone cellular activity.  Efforts to study the effects of chronic inflammatory conditions on bone physiology have lead to the evaluation of potential links between the simultaneous osteopenia and cardiovascular disease associated with aging.  Strategies utilizing plant-based and other novel compounds with anti-inflammatory and antioxidant properties to prevent and/or treat osteoporosis are also under investigation.

Education

Smith BJ, Lightfoot SA, Lerner MR, Denson KD, Morgan DL, Hanas JS, Bronze MS, Postier RG, Brackett DJ. Induction of cardiovascular pathology in an in vivo model of low-grade chronic inflammation. J Cardiovascular Pathology (in press) 2007.

Droke EA,Hager KA, Lerner MR, Lightfoot SA, Stoecker BJ, Brackett DJ, Smith BJ. Soy Isoflavones Avert Chronic Inflammation-induced Bone Loss and Vascular Disease. J of Inflammation (in press) 2007.

Denson KD, Morgan D, Cunningham R, Nigliazzo A, Brackett DJ, Lane M, Smith BJ, Albrecht R. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J of Surgery (in press) 2007.

Bu SY, Lucas EA, Franklin M, Marlow D, Brackett DJ, Boldrin EA, Devareddy L, Arjmandi BH, Smith BJ.  Restoration of bone mass and microarchitecture by dietary dried plum is comparable to PTH in osteopenic orchidectomized rats. Osteoporosis Int 2007, 18(7):931-42.

Franklin M, Bu SY, Lerner MR, Lancaster EA, Bellmer D, Marlow D, Arjmandi BH, Brackett DJ, Lucas EA, and Smith BJ;  Dried plum down-regulates RANKL and OPG and prevents bone loss in a male model of osteoporosis.  Bone 2006 39(6):1331-2.

Juma S, Madihally SV, Soung DY, Munson ME, Khalil DA, Smith BJ, Arjmandim BH. Link between estrogen, its receptors, and osteoarthritis. Steroids 2005 (in press).

Devareddy L, Marlow D, Khalil D, Smith BJ, Lucas EA, Soung DY, Arjmandi BH. Soy moderately improves bone mass and microstructural properties in an ovariectomized rat model of osteoporosis. Bone 2006, May;38(5):686-93.

Smith BJ, Lerner MR, Bu SY, Lucas EA, Hanas JS, Lightfoot SA, Bronze MS, Postier RG, Brackett, DJ. Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. Bone 2006 Mar;38(3):378-86.

Smith BJ, Lucas EA, Turner RT, Evans GL, Lerner MR, Brackett DJ, Stoecker BJ, Arjmandi BH. Vitamin E provides protection for bone in mature hindlimb unloaded male rats. Calcified Tissue Int 2005 Apr;76(4):272-279.

Deyhim F, Smith BJ, Soung do Y, Juma S, Devareddy L, Arjmandi BH. Ipriflavone modulates IGF-I but is unable to restore bone in rats. Phytother Res. 2005 Feb;19(2):116-20.

Arjmandi BH, Lucas EA, Khalil DA, Devareddy L, Smith BJ, McDonald J, Arquitt A, Payton ME, Mason C. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J. 2005 Feb 23;4(1):8 [Epub ahead of print].

Khalil DA, Lucas EA, Smith BJ, Soung DY, Akhter MP, Recker R, Arjmandi BH. Soy isoflavones ameliorate bone loss in aged orchidectomized male rats. Calcif TissInt. 2005;76(1):56-62.