Hongtao Liu, MD, PhD Post-Doctoral Research Fellow
Mailing Address: 941 Stanton L. Young Blvd., BSEB 330 Oklahoma City, OK 73104	Telephone: (405) 271-8001 ext 52604 Fax: (405) 271-3973
Email: hongtao-liu@ouhsc.edu

Research Interests

1. The role of ubiquitin-proteasome-system in diabetes.
2. Bioactive natural products that protect against cardiovascular diseases.

Education

Liu H, Yu S, Zhang H and Xu J. (2012). Angiogenesis impairment in diabetes: Role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. PLoS ONE. 7(10):e46720. PMID: 23056421. PMCID: PMC3463541

Liu H, Yu S, Xu W and Xu J. (2012). Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 32 (9):2131-2140. PMID: 22772755. PMCID: PMC3432586  

Ma P, Liu H, Wei P, Xu Q, Bai X, Du YG, and Yu C. (2011). Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways. Carbohydrate Polymer, (in press).

Liu HT, Huang P, Ma P, Liu QS, Yu C, and Du YG. (2011). Chitosan oligosaccharides suppress lipopolysaccharide-induced interleukin-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases. Acta Pharmacologica Sinica. Doi: 10.1038/aps.10 (in press).

Liu HT, He JL, Li WM, Yang Z, Wang YX, Yin J, Du YG, and Yu C. (2010). Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways. Inflammation Research, (59):451–461.

Liu HT, He JL, Li WM, Yang Z, Wang YX, Bai XF, Yu C, and Du YG. (2010). Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis. Carbohydrate Polymer, (80):1062–1071.

Liu HT, Li WM, Huang P, Chen WJ, Liu QS, Bai XF, Yu C, and Du YG. (2010). Chitosan oligosaccharides inhibit TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways. Carbohydrate Polymer, (81): 49–56.

Liu HT, He JL, Chen WJ, Li WM, Yang Z, Wang YX, Du YG, and Yu C. (2010). Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species. Journal of Ethnopharmacology, (129): 335–343.

Xu QS, Ma P, Yu WT, Tan CY, Liu HT, Xiong CN, Qiao Y, and Du YG. (2010). Chitooligosaccharides protect human embryonic hepatocytes against oxidative stress induced by hydrogen peroxide. Mar Biotechnol,12: 292-298.

Liu HT, Li WM, Xu G, Li XY, Bai XF, Wei P, Yu C, and Du YG. (2009). Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacological Research, (59):167–175.

Liu HT, Li WM, Li XY, Xu QS, Liu QS, Bai XF, Yu C, and Du YG. (2009). Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases. Basic & Clinical Pharmacology & Toxicology, (106): 362–371. 

Li WM, Liu HT, Li XY, Wu JY, Xu G, Teng YZ, Ding ST, and Yu C. (2009). The effect of Tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells. Basic & Clinical Pharmacology & Toxicology, 106, 45–52.

Li XY, He JL, Liu HT, Li WM, and Yu C. (2009). Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-κB signaling pathways. Journal of Ethnopharmacology, 125: 83–89.

Liu HX, Liu Y, Zhang JW, Li W, Liu HT, and Yang L. (2008). UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes. Drug Metab Dispos, (36):1562-1569.

Li W, Liu Y, Zhang JW, Gao Y, Ge GB, Liu HX, Huo H, Liu HT, Wang LM, Sun J, Wang Q, and Yang L. (2008). Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica. (38):1551-1565.

Zhang JW, Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, and Yang L. (2008). Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metab Dispos, (36):2292-2298.

Zhang JW, Liu Y, Chen J, Li W, Ma H, Liu HT, Sun J, Wang LM, He YQ, Wang Y, Wang ZT, and Yang L. (2007). Inhibition of human liver cytochrome P450 by star fruit juice. J Pharm Pharm Sci. (10):496-503.

Abstracts

Liu HT, Yu SJ, and Xu J. (2012). Autophagy-mediated Reduction of Vascular Endothelial Growth Factor Receptor 2 Impairs Diabetic Angiogenesis. American Diabetes Association's 72nd Scientific Sessions, June 8−12, 2012, Philadelphia, Pennsylvania.

Xu J, Pantalia M, Lau A, Eby B, Skaggs C, Yu SJ, Liu HT, Ma JX and Lau K (2011). Diabetic Nephropathy (DN) in Insulin-Deficient Mouse Models: Longitudinal Functional & Ultrasonic Documentation of Progressive Decline in Glomerular Filtration Rate (GFR) & the Role of Reduced Oxidative/Nitrosative Stress in Metformin Renoprotection. The American Society of Nephrology 2011 Meetings Philadelphia, PA

Liu HT, Yu SJ, and Xu J. (2011). Hyperglycemia induced 26S proteasome activation is an early event in streptozotocin−treated mice. American Diabetes Association's 71st Scientific Sessions, June 24−28, 2011, San Diego, California (this abstract has also been selected to be showcased in a Guided Audio Poster Tour).

Liu HT, Yu SJ and Xu J.* (2011). Hyperglycemia activates 26S proteasome in STZ-treated mice. Central Region IDEA Conference. Omaha, NE, May 23-25, 2011. (*Corresponding author and selected as an oral presentation).