Bin Zhang, BS Graduate Student
Mailing Address: 941 Stanton L. Young Blvd., BSEB 331 Oklahoma City, OK 73104	Telephone: (405) 271-5896 ext 47791 Fax: (405) 271-3973
Email: bin-zhang@ouhsc.edu

Research Interests

My dissertation work is to investigate the role of an angiogenic inhibitor in diabetic retinopathy, and further I am focusing on the Wnt signaling pathway to explain the mechanism.

In summary, SERPINA3K, an extracellular serin proteinase inhibitor, is also an antagonist of the Wnt coreceptor named LRP6. With its Wnt-inhibitory function, SERPINA3K plays important roles in attenuating abnormal angiogenesis, inflammation and fibrosis, which are major causes of vision loss in diabetic retinaopathy. It suggests a therapeutic potential of SERPINA3K in DR. SERPINA3K also displays the neurotrophic activity through the inhibition of PLC/calcium pathway, suggesting a prospect on the neuron protection study in diabetic retinaopathy.

Education

Jenkins AJ, McBride JD, Januszewski AS, Karschimkus CS, Zhang B, O'Neal DN, Nelson CL, Chung JS, Harper CA, Lyons TJ, and Ma J-x. (2010). Increased serum Kallistatin levels in patients with Type 1 Diabetes and its vascular complications. J. Angiogenesis Res., under review.

Park K, Lee K, Zhang B, Zhou T, He X, Gao G, and Ma J-x. (2010). Identification of Pigment Epithelium-Derived Factor as a Novel LRP6 Antagonist. J. Clin. Invest., in revision.

Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, and Ma J-x. (2010). Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc. Natl. Acad. Sci. USA, Epub ahead of print.

Zhang B, Zhou K, and Ma J-x. (2010). Inhibition of CTGF over-expression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway. Diabetes, Epub ahead of print.  

Zhou T, Hu Y, Chen Y, Zhou K, Zhang B, Gao G, and Ma J-x. (2009). The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., Epub ahead of print.

Zhang B, Hu Y, and Ma J-x. (2009). Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. Invest. Ophthalmol. Vis. Sci., 50, 3943-3952.

Zhang B, and Ma J-x. (2008). SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PLoS ONE, 3, e4077.

Zhang B, Wei H, Zheng X, Zhang J, Sun R, and Tian Z. (2005). The inhibitory effects of synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, on function of NK cells . Peptides, 26(3), 405-412.