James Chodosh, M.D.

JAMES CHODOSH, M.D.
Professor, Department of Ophthalmology
Telephone: (405) 271-1095
FAX: (405) 271-3680
Email: james-chodosh@ouhsc.edu

Research Interests: Molecular pathogenesis of viral ocular infections
Teaching: Immunology, Ophthalmology

  • Research
  • Curriculum Vitae
  • Publications

    Research

    Dr. Chodosh completed a clinical training fellowship in cornea/external disease and a research fellowship in molecular virology. His primary research focus examines the interactions between virus particles, and cells of the cornea and mucosal immune system. As an ophthalmologist with a subspeciality in corneal diseases, Dr. Chodosh provides the MPEIR Center with a clinical perspective as well as expertise in anterior segment and ocular surface disease.

    Curriculum Vitae

    Full CV can be found here.


    Research Support

    Immunopathogenesis of Adenovirus Keratitis: 2 RO1 EY 013124-06; June 1, 2001 – June 30, 2011; $295,357 total direct cost (06-07); 50% effort; Principal Investigator.

     

    Genetics of Ocular Adenoviruses: R03 EY015222-03; January 1, 2004 – December 31, 2006; $100,000 annual direct costs; 10 % effort; Principal Investigator.

      

    Mentoring Vision Research in Oklahoma: P20 RR017703-05; September 15, 2002 – June 30, 2007; Mentor to Wei Cao, Ph.D.; 5% effort; Anderson: PI.

     

    Research to Prevent Blindness Physician Scientist Merit Award; July 2005; $55,000.

    Publications (since 2000)

    Chodosh J, Gan Y-J, Holder VP, Sixbey JW. Patterned entry and egress by Epstein-Barr virus in polarized CR2-positive epithelial cells. Virology 2000;266:387-396.Chodosh J, Miller D, Tu EY,

    Culbertson WG. Tobramycin-responsive Fusarium oxysporum keratitis. Can J Ophthalmol 2000;35:29-30

    Chodosh J, Astley RA, Butler MG, Kennedy RC. Adenovirus keratitis: a role for interleukin-8. Invest Ophthalmol Vis Sci 2000;41:783-789.

    Lemley HL, Chodosh J, Wolf TC, Bogie CP, Hawkins TC,. Partial dislocation of laser in situ keratomileusis flap by air bag injury. J Ref Surg 2000;16:373-374.

    Stroop WG, Chen TM, Chodosh J, Kienzle TE, Stroop JL, Ling J-L, Miles DA. Polymerase chain reaction assessment of herpes simplex virus type 1 corneal infection in animals treated with rose bengal and lissamine green B. Invest Ophthalmol Vis Sci 2000;41:2096-2102.

    Herpetic Eye Disease Study Group. Oral acyclovir for herpes simplex eye disease: Effect on prevention of epithelial keratitis and stromal keratitis. Arch Ophthalmol 2000;118:1030-1036.

    Herpetic Eye Disease Study Group. Psychological stress and other potential triggers for recurrences of herpes simplex virus eye infections. Arch Ophthalmol 2000;118:1617-1625.

    Herpetic Eye Disease Study Group. Predictors of recurrent herpes simplex virus keratitis. Cornea 2001;20:123-128.

    Fite SW, Chodosh J, Photorefractive keratectomy for myopia in the setting of Thygeson’s superficial punctate keratitis. Cornea 2001;20:425-426.

    Chodosh J. Cat’s tooth keratitis: Human corneal infection with Capnocytophaga canimorsus. Cornea 2001;20:661-663.

    Ruan X, Chodosh J, Callegan MC, Booth MC. Lee TD, Kumar P, Gilmore MS, Pereira HA. Corneal expression of the inflammatory mediator CAP37 in a rabbit model of Staphylococcus aureus keratitis. Invest Ophthalmol Vis Sci 2002;43:1414-1421.

    Chodosh J, Kennedy RC. The conjunctival lymphoid follicle in mucosal immunology. DNA Cell Biol 2002;21:421-433.

    Natarajan K, Ghalayini AJ, Sterling RS, Holbrook RM, Kennedy RC, Chodosh J. Activation of focal adhesion kinase in adenovirus-infected human corneal fibroblasts. Invest Ophthalmol Vis Sci 2002;43:2685-2690. [comment: Inside IOVS]

    Fortney, A, Chodosh J. Conjunctival ulceration as a sign of recurrent Wegener’s granulomatosis. Cornea 2002;21:623-624.

    Natarajan K, Shepard LA, Chodosh J. The use of DNA array technology in studies of ocular viral pathogenesis. DNA Cell Biol 2002;21:483-490.

    Hampton D, Adesina, A, Chodosh J. Conjunctival sporotrichosis in the absence of antecedent trauma. Cornea 2002;21:831-833.

    Natarajan K, Chodosh J, Kennedy RC. Innate immunity in the cornea: Putative role for keratocytes in the chemokine response to viral infection of the human corneal stroma. In: Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Basic Science and clinical Relevance, eds: Sullivan D et al. Kluwer Academic/Plenum, New York, 2002, vol. 506, pg. 745-751. 

    Astley RA, Kennedy RC, Chodosh J. Structural and cellular architecture of conjunctival lymphoid follicles in the baboon (Papio anubis). Exp Eye Res 2003;76:685-694.

    Natajaran K, Rajala M, Chodosh J. c-Src activation induces early IL-8 expression in adenovirus-infected human corneal fibroblasts. J Immunol 2003;170:6234-6243.

    Carr DJJ, Chodosh J, Ash J, Lane TE. Anti-CXCL10 antibody blocks dissemination of herpes simplex virus type 1 (HSV-1) from the cornea to the retina. J Virol 2003;77:10037-10046.

    Espana EM, Chodosh J, Mateo AJ, Di Pascuale MA, Tseng SCG. Retinoides Topicos como Tratamiento no Invasivo de la Neoplasia Intraepithelial Conjuntival. Microcirugia Ocular  2003;11:169-174.

    Nazir SA, Murphy S, Siatkowski RM, Chodosh J, Siatkowski RL. Ocular rosacea in childhood. Am J Ophthalmol 2004; 137:138-144.

    Stone DU, Chodosh J. Oral tetracyclines for ocular rosacea: an evidence-based review of the literature. Cornea 2004;23:106-109.

    Chodosh J, Burris RD. Ocular melanocytosis. New Eng J Med 2004;350:809.

    Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Palva CS, Bartels SP, Micuda T, Proskin HE, Vogel R. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5% and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol 2004;138:444-457.

    Stone DU, Chodosh J. Ocular rosacea: an update on pathogenesis and therapy. Curr Opin Ophthalmol 2004;15:499-502.

    Pereira HA, Ruan X, Gonzalez ML, Chodosh J. Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37. Invest Ophthalmol Vis Sci 2004;45:4284-4292.

    Stone DU, Butt AL, Chodosh J. Ocular surface squamous neoplasia; A standard of care survey. Cornea 2005;24:297-300.

    Astley RA, Chodosh J. Selective uptake of iron oxide by rabbit conjunctival lymphoid follicles. Cornea 2005;24:334-336.

    Stone DU, Chodosh J. Epibulbar nodular fasciitis in the setting of floppy eyelids: a common denominator. Cornea 2005;24:361-362.

    Xiao J, Natarajan K, Rajala MS, Astley RA, Ramadan RT, Chodosh J,  Vitronectin: a possible determinant of adenovirus type 19 tropism for human corneal epithelium. Am J Ophthalmology 2005;140:363-369.

    Xiao J, Chodosh J. JNK regulates MCP-1 expression by adenovirus type 19 infected human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005;46:3777-3782.

    Rajala MS, Rajala RVS, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type-19 infection requires phosphoinositide-3-kinase/Akt activation. J Virol 2005;79:12322-12341.

    Nour M, Chodosh J. Chemokine pathways in corneal fibroblasts. The Ocular Surface 2005;3:S149-S151.

    McDermott AM, Perez V, Huang AJW, Pflugfelder SC, Stern ME, Baudouin C, Beuerman RW, Burns AR, Calder VL, Calonge M, Chodosh J, Coster DJ, Dana R, Hazlett LD, Jones DB, Kim SK, Knop E, Li D-Q, Mitchell BM, Niederkorn JY, Pearlman E, Wilhelmus KR, Kurie E. Pathways of corneal and ocular surface inflammation: a perspective from the Cullen symposium. The Ocular Surface 2005;3:S131-S138.

    Butt AL, Chodosh J. Adenoviral keratoconjunctivitis in a tertiary care eye clinic. Cornea 2006;25:199-202.

    Callegan MC, Cochran DC, Kane ST, Ramadan RT, Chodosh J, McLean C, Stroman DW. Virulence factor profiles and antimicrobial susceptibilities of ocular Bacillus isolates. Curr Eye Res 2006;31:693-702.

    Chodosh J. Human adenovirus type 37 and the Balb/c mouse: progress towards a restricted adenovirus keratitis model. (In Press: Thesis accepted by the American Ophthalmological Society).

    Rajaiya J, Chodosh J. New paradigms in infectious eye disease: adenoviral keratoconjunctivitis. Arch Soc Esp Oftalmol 2006;81:493-498.

    Chintakuntlawar AV, Astley RA, Chodosh J. Adenovirus type 37 keratitis in the C57BL/6J mouse. 2006 Invest Ophthalmol Vis Sci 2007 (In Press).

    Zhou X, Li F, Ge J, Sarkisian SR, Tomita H, Zaharia A, Chodosh J, and Cao W. Retinal Ganglion Cell Protection by17-beta-Estradiol in a Mouse Model of Inherited Glaucoma. 2007 J Neurobiol (In Press)

    BOOK CHAPTERS

    Chodosh J. Viral Keratitis. In Bascom Palmer Atlas of Ophthalmology. Ed: Parrish RK. Current Medicine, Boston, 2000, p.64-70.

    Chodosh J. Infectious Diseases of the External Eye: Basic Concepts. In Section 8, Cornea and External Diseases, Basic and Clinical Science Course, American Academy of Ophthalmology, San Francisco, CA, 2002, chapter VI, p. 105-128

    Chodosh J. Infectious Diseases of the External Eye: Clinical Aspects. In Section 8, Cornea and External Diseases, Basic and Clinical Science Course, American Academy of Ophthalmology, San Francisco, CA, 2002, chapter VI, p. 129-152

    Chodosh J. Tumor Cell Biology and Diagnostic Approaches to Ocular Surface Neoplasia. In Section 8, Cornea and External Diseases, Basic and Clinical Science Course, American Academy of Ophthalmology, San Francisco, CA, 2002, chapter X, p. 231-237.

    Chodosh J. Clinical Approach to Neoplastic Disorders of the Conjunctiva and Cornea. In Section 8, Cornea and External Diseases, Basic and Clinical Science Course, American Academy of Ophthalmology, San Francisco, CA, 2002, chapter XI, p. 239-262.

    Chodosh J. Ocular Virology. In Albert and Jakobiec’s Principles and Practice of Ophthalmology. 3rd Edition. Eds: Albert DM, Miller JW. Elsevier, London, (in press).

    Chintakuntlawar AV, Robinson CM, Chodosh J. Eye Infections. In Encyclopedia of Virology, 3rd Edition (in press).