Juvenile Xanthogranuloma lesions appear as yellow-orange nodules in children that histologically show dermal foam cells . Since these lesions are very vascular, then have an orange hue to them. Touton giant cells (1,2) may be seen. These are large multinucleated cells with a ring of nuclei separating a central eosinophilic cytoplasm from a clear or foamy peripheral cytoplasm. Patients may also have iris lesions (1) that can spontaneously bleed, resulting in a hyphema. Back to Eyelid