Graduate Student Seminar: "Immunomodulation by a TLR4-interacting SPA4 peptide." Presented by Vijay Ramani, graduate student, Dept. of Pharmaceutical Sciences, OU College of Pharmacy (Graduate advisor: Dr. Shanjana Awasthi)
Seminar is in CPB 101 (OKC) and 2H37 (Tulsa)
Abstract: Immune mechanisms involved in infection, inflammation and cancer are associated with an increased level of Toll-like receptor (TLR4). The TLR4 is required for recognition of pathogens, pathogen-derived ligands, and endogenous stress signals, and induction of innate immunity. Activation of TLR4 can also lead to an exaggerated and chronic inflammation. Several TLR4-modulators and antagonists are currently being tried mainly for the anti-inflammatory activity. A TLR4-interacting SPA4 peptide was recently derived from the interface of SP-A-TLR4 complex. Recent results obtained from cell systems and mouse models of infection and inflammation demonstrate that the SPA4 peptide reduces inflammation and pathogen-burden, improves tissue pathology and alleviates clinical symptoms. My seminar will include an overview of these findings and possible mechanisms of SPA4 peptide activity.