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Hongliang Li, MD, PhD
Assistant Professor of Research


HongliangLilarge
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Mailing Address:
The Childrens Hospital/Everett Tower
1200 N. Everett Drive, ET 6E109
Oklahoma City, OK 73104-5068

Telephone:
(405) 271-5896 ext 52269
Fax:
(405) 271-7455
Email: hongliang-li@ouhsc.edu

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Research Interests

  1. Autoimmunity incardiovascular disease: focus upon G-protein coupled receptors
  2. Molecular mechanisms of obesity and diabetes regulation
  3. Defective autophagy-dependent mitochondrial clearance and diabetic cardiomyopathy

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Education

  MD - Xinjiang Medical University, Urumqi, China
  PhD - Sichuan University, Chengdu, China
  Postdoctoral Fellow - Boston University, Boston, MA/OUHSC, Oklahoma City, OK

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Recent Publications
 

Fedorowski A, Li H, Yu X, Koelsch KA, Harris VM, Liles C, Murphy TA, Quadri SMS, Scofield RH, Sutton R, Melander O, Kem DC. Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace. 2017;19(7):1211-1219.

Li H, Murphy T, Zhang L, Huang B, Veitla V, Scherlag BJ, Kem DC, Yu X. β1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits. Endocrinology. 2016;157(1):16-22.

Li H, Zhang L, Huang B, Veitla V, Scherlag BJ, Cunningham MW, Aston CE, Kem DC, Yu X. A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J Interv Card Electrophysiol. 2015;44(3):205-12.

Liles C, Li H, Veitla V, Liles JT, Murphy TA, Cunningham MW, Yu X, Kem DC. AT2R Autoantibodies Block Angiotensin II and AT1R Autoantibody-Induced Vasoconstriction. Hypertension. 2015;66(4):830-5.

Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW, Yu X. A novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension. 2015;65(4):793-9.

Zhang L, Po SS, Wang H, Scherlag BJ, Li H, Sun J, Lu Y, Ma Y, Hou Y. Autonomic remodeling: How atrial fibrillation begets atrial fibrillation in the first 24 hours. J Cardiovasc Pharmacol. J Cardiovasc Pharmacol.2015;66(3):307-15.

He C, Li H, Viollet B, Zou MH, Xie Z. AMP-activated Protein Kinase Suppresses Vascular Inflammation in vivo by Inhibiting Signal Transducer and Activator of Transcription-1. Diabetes.2015; 64(12):4285-97.

Li H, Yu X, Cicala MV, Mantero F, Benbrook A, Veitla V, Cunningham MW, Kem DC. Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in primary aldosteronism. J Am Soc Hypertens. 2015; 9(1):15-20.

Li YD, Ji YT, Zhou XH, Li H, Zhang HT, Xing Q, Hong YF, Tang BP. TNNT2 Gene Polymorphisms are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in Kazak and Han Chinese. Med Sci Monit. 2015;21:3343-7.

Galloway A, Li H, Vanderlinde-Wood M, Khan M, Benbrook A, Liles C, Zillner C, Rao V, Cunningham MW, Yu X, Kem DC. Activating autoantibodies to the β1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism. Endocrine.2015; 49(2):457-63.

Li H, Min Q, Ouyang C, Lee J, He C, Zou MH, Xie Z. AMPK Activation Prevents Excess Nutrient-induced Hepatic Lipid Accumulation by Inhibiting mTORC1 Signaling and Endoplasmic Reticulum Stress Response. Biochim Biophys Acta. 2014;1842 (9):1844-54.

Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R, Yu X. Atrial Tachyarrhythmias Induced by the Combined Effects of β1/2-adrenergic Autoantibodies and Thyroid Hormone in the Rabbit. J Cardiovasc Transl Res. 2014; 7(6):581-9.

Kem DC, Li H, Velarde-Miranda C, Liles C, Vanderlinde-Wood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in primary aldosteronism. J Clin Endocrinol Metab. 2014; 99(5):1790-7.

Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim, S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc. 2014; 3(1): e000755.

Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The Propensity for Inducing Atrial Fibrillation: A Comparative Study on Old versus Young Rabbits. J Aging Res. 2014;684918.

Li H, Lee J, He C, Zou MH, Xie Z. Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids. Am J Physiol Endocrinol Metab. 2014; 306(2):E197-209.

Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced β1-adrenergic autoantibody expression in the rabbit. Am J Physiol Heart Circ Physiol. 2014; 306(3):H422-428.

Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem. 2013; 288(42): 30734 -30741.

Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to β2-adrenergic receptor in the rabbit. Heart Rhythm. 2013; 10(3):436-441.

He C, Zhu H, Zhang W, Okon I, Wang Q, Li H, Le YZ, Xie Z. 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. Am J Pathol. 2013;183(2):626-637.

Li H, Yu X. Emerging role of JNK in insulin resistance. Curr Diabetes Rev.2013;9(5):422-428.

He C, Zhu H, Li H, Zou MH, Xie Z. Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes. 2013; 62(4):1270 -1281.

Yu X, Stavrakis S, Hill MA, Huang S, Reim, S, Li H, Khan M, Hamlett SR, Cunningham MW, Kem DC. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. J Am Soc Hypertens. 2012;6(1):40-47.

Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X. Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension. 2012; 59(2):402-408.

Li H, Xu M, Lee J, He C, Xie Z. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. Am J Physiol Endocrinol Metab. 2012; 303(10):E1234-44.

Shen X, Li H (Co-first author), Pan L, Hong J, Xiao J, Hermansen K, Jeppesen PB, Li GW. Glucotoxicity and α cell dysfunction: involvement of the PI3K/Akt pathway in glucose-induced insulin resistance in rat islets and clonal αTC1-6 cells. Endocr Res. 2012; 37(1):12-24.

Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, Kem D, and Zou M-H. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 2011; 60(6):1770-1778.

Zou MH, Li H, He C, Lin M, Lyons TJ, Xie Z. Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes. Am J Pathol. 2011; 179(6): 2835-2844.

Gregg EW, Wang J, An Y, Zhang P, Yang W, Li H, Li H, Jiang Y, Shuai Y, Zhang B, ZhangJ, Gerzoff   RB, Roglic   G, Hu   Y, Li  G, Bennett   PH.   Long-term effects of   a randomised trial of   a   6 year lifestyle intervention in impaired glucose tolerance on diabetes related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia. 2011; 54(2):300-7.

Li H, Li H, Bao YG, Zhang XX, Yu YR. Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-κB pathway in rat aorta. Int J Cardiol. 2011; 152(2):218-224.

Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362(12):1090-101. Collaborators(142): Xiao J, Yang Z, He J, ChenCS, Xiang K, Chen J, Pan C, Fu Z, Yang W, Xiao J, Yang Z, Ruan D, Li Y, Bu S, Li H, et al.

Su JY, Li H (Co-first author), Yang WY, Xiao JZ, Du RQ, Shen XX, Cai Z, Zhang L, Shu J. Role and mechanism of uncoupling protein 2 on the fatty acid-induced dysfunction of pancreatic alpha cells in vitro. Chin Med J (Engl). 2010; 2416-23.

Wang H, Li H (Corresponding author), Hou Z, Pan L, Shen and Li G. Role of oxidative stress in elevated blood pressure induced by high free fatty acids. Hypertens Res. 2009;32(2):152-158.

Hou Z, Li H (Co-first author), Gao L, Pan L, Zhao JJ, Li GW. Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol Cell Endocrinol. 2008; 291(1-2):71-78.

Li G, Zhang P, Wang J, Gregg E, Yang W, Gong Q, Li H, Li H, Jiang Y, An Y, Shuai Y, Zhang B, Zhang J, Thompson T, Gerzoff B, Gojka R, Hu Y, and Bennett PH. The long term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008; 371(9626):1783-1789.

Funding Agencies:

  • Oklahoma Center for the Advancement of Science and Technology
  • AHA Postdoctoral Fellowship


 
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