Zhonglin Xie, MD, PhD Assistant Professor
Mailing Address: 941 Stanton L. Young Blvd., BSEB 302B Oklahoma City, OK 73104-5020	Telephone: (405) 271-3077 Fax: (405) 271-3973
Email: zxie@ouhsc.edu

Research Interests

1. Molecular mechanism of AMP-activated kinase activation and its role in cardiovascular diseases.

2. Oxidative stress and diabetic cardiomyopathy.

3. Matrix modulation and cardiac remodeling

Education

He C, Choi CH and Xie Z. (2010). Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type II diabetic patients. Am J Pathol. Mar 26. [Epub ahead of print]

Wang S, Zhang M,  Liang B,  Xu J, Xie Z, Liu C, Viollet B, Yan D, and Zou MH. (2010). AMPKα2 deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction in vivo: Role of 26S Proteasomes. Circ Res. 106:1117-28.

Dong Y, Zhang M, Liang B, Xie Z, Zhao Z, Asfa S, Choi HC, and Zou MH. (2010). Reduction of AMP-activated protein kinaseα2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation. 12:792-803.

Xie Z, Dong Y, Scholz R, Neumann D, and Zou MH. (2009). Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for its Nucleus Export and the Activation of AMP-activated Protein Kinase. Molecular and Cellular Biology. 29:525-531.

Xie Z, Song P, Zhang J, and Zou M. H. (2008). Up-regulation of Mitochondrial Uncoupling Protein-2 by the AMP-activated Protein Kinase in Endothelial Cells Attenuates Tyrosine Nitration of Prostacyclin Synthase in Diabetes. Diabetes. 57:3222-30.

Zhang J, Xie Z, Dong Y, Wang S,  Liu C, and Zou MH. (2008). Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. J Biol Chem. 283:27452-61.

Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, and Zou MH. (2008). Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J Biol Chem. 283:20186-97.

Xie Z, Dong Y, Scholz R, Neumann D, and Zou MH. (2008). Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation. 117:952-62.

Song P, Xie Z, Wu Y, Xu J, Dong Y, and Zou MH. (2008). Protein Kinase C ζ-dependent LKB1 serine 428 phosphorylation increases lkb1 nucleus export and apoptosis in endothelial cells . J Biol Chem. Mar 5; 283:12446-55. [Epub ahead of print] PMID: 18321849.

Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, and Zou MH. (2007). Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res. 102:328-37.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, and Zou MH. (2007). Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation. 116:1585-95.

Xie Z, Davis B, Zhang M, Cui MZ, Riek U, Neumann D, Shi C, Hou X, Cohen R, and Zou MH. (2006). Activation of Protein Kinase-C By Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase In Endothelial cells. J. Biol Chem. 281:6366-75.

Xu J, Xie Z, Reece R, Pimental D, and Zou MH.  (2006). Hypochlorous acid uncouples endothelial nitric oxide synthase:  Role of vascular NAD(P)H oxidase-derived superoxide and peroxynitrite. Atherosclerosis, Thrombosis, and Vascular Biology. 26:2688-2695.

Davis B, Xie Z, Wiles IV, WG, Viollet B, and Zou MH. (2006). Activation of the AMP-activated Kinase By Anti-diabetic Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo By Promoting The Association Of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase. Diabetes 55:496-505.

Xu J, Xie Z, Reece R, and Zou MH. (2005). Hypochlorite Activates Vascular NADP(H) Oxidase and Uncouples Endothelial Nitrite Oxide Synthase: Role of Reactive Nitrogen Species.  Circulation 112:II-141.