There are two distinct purposes for the
database search, both of which are important to satisfy Federal
To ensure that there are no scientifically viable alternatives
to the use of animals
To ensure that the proposed study does not unnecessarily duplicate
previous work .
Both requirements must be met before IACUC approval
can be obtained.
At least two independent databases must
be searched. Searches of the PubMed database
automatically include Medline as one of the data sources and therefore
Medline is not an independent database and does not fulfill the
requirement for searching two databases if PubMed is used as one
of the databases.
Point Presentation on Database Searching
link provided below directs you to the OUHSC Library's webpage that
contains the database search engines.