Diabetes COBRE

SECTION OF ENDOCRINOLOGY AND DIABETES
UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER
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The Associate Director


Timothy J. Lyons, MD, FRCP

     The Associate Director of the COBRE is Timothy J. Lyons, MD, FRCP.  Dr. Lyons is a physician scientist who fulfills a number of roles at OUHSC. He is Chickasaw Chair of Diabetes Studies, Professor and Chief of the Section of Endocrinology and Diabetes in the Department of Medicine, and Director of the Harold Hamm Diabetes Center.  Dr. Lyons is a diabetologist/endocrinologist with extensive experience in diabetes research. His interests are in the vascular complications of diabetes, and specifically, in the role of oxidation, glycation, glycoxidation, and lipoxidation in the promotion of micro- and macro-vascular damage. He has conducted numerous studies on the roles of these stresses using human, animal and cell culture models. Recent work has addressed the roles of specific advanced glycation end-products (AGE products) and oxidation products in insoluble collagen as long-term markers of stresses leading to complications.  Other studies address the role of modified (i.e. oxidized and/or glycated) LDL in diabetic retinopathy. Some of his work has a large clinical component: he has been involved in DCCT/EDIC since its inception and has served as Co-PI and Project Leader on an NIH-funded Program Project that has been collaborative with DCCT/EDIC since 1996 and with the VA Diabetes Trial (VADT) since 2001, and for which he has current RO1 support. He has recently completed the clinical and initial laboratory phases of a large, prospective study of over 150 pregnancies in women with Type 1 diabetes, addressing markers and mechanisms of pre-eclampsia. He leads a NIH-funded project now under way to study pregnancies in American Indian and other minority women in Oklahoma. He also has administrative responsibility as a clinical researcher. He recently served as Chair of the ADA’s Grant Review Committee, the ADA’s Research Policy Committee, and the Organizational Committee for ADA’s Annual Scientific Sessions. Also, for three years, he has chaired an NIH Study Section for studies ancillary to large clinical trials. His work as GCRC Program Director from 2004-2010 led to successful renewal of the GCRC NIH funding and brought further breadth of experience. The OUHSC GCRC was unique in the nation in having a Special Populations Unit to promote research partnerships with the American Indian communities in Oklahoma, and Dr. Lyons has worked actively to expand studies within these communities. This work will continue and grow with the establishment of the HHDC Clinical and Translational Research Unit, now in process. Dr. Lyons’ clinical research skills are highly complementary to the basic science skills of Dr. Ma. Drs. Lyons and Ma have worked closely together to lead the COBRE and to establish the Diabetes Research Program of the Harold Hamm Diabetes Center.

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