Criteria for article
assessment |
Description |
1 |
1)
Ingestion of candidate substance preceded thrombocytopenia, and 2) Platelet
count recovered to normal or to the baseline level if the patient had an
established disorder with chronic mild thrombocytopenia |
2 |
1)
Candidate substance was only suspected agent ingested prior to onset of
thrombocytopenia or 2) Other
agents were ingested prior to onset of thrombocytopenia but were reintroduced,
or continued, after discontinuation of candidate substance with sustained
normal platelet count |
3 |
Other
etiologies for thrombocytopenia were excluded |
4 |
Re-exposure
to the substance resulted in recurrent acute thrombocytopenia |
5 |
Substance-dependent
platelet-reactive antibodies were identified |
Levels of evidence |
Description |
1 [Definite] |
Criteria
1, 2, 3, 4 or 1, 2, 3, 5 met |
2 [Probable] |
Criteria
1, 2, 3 met, but not
criteria 4 or 5 |
3 [Possible] |
Criterion
1 met, but not criteria 2 and 3, and not criteria 4 or
5 |
4 [Unlikely] |
Criterion
1 not met or re-exposure
does not result in recurrent thrombocytopenia |
5 [Excluded] |
Criteria
for excluding articles from review: 1. Insufficient data to evaluate an
association between the reported substance and thrombocytopenia 2. Platelet count not less than 100,000/µl 3. Substance is known to be [a]toxic, [b]
illegal, or [c] is available only for research 4. Substance was taken as an overdose with
intention to harm |