WHAT IS THE FUTURE FOR PATIENTS WHO RECOVER FROM TTP-HUS?
Some patients may have another episode of TTP-HUS after they recover. Most recurrences happen within the first year after the initial episode, and almost all occur in patients who have the autoimmune cause for their TTP-HUS, with deficient activity of their enzyme, called ADAMTS13. Patients with other causes of TTP-HUS almost never have another episode. Patients with recurrences do well, because their disease was responsive to treatment the first time and because there is no delay in diagnosis the next time. Because TTP-HUS often occurs in young women, some of whom are pregnant when the first diagnosis is made, the question about safety of subsequent pregnancies is critical. Our experience is that TTP-HUS can recur during pregnancy, but this is uncommon. Most women have uncomplicated, successful pregnancies.
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