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Drug-Induced Thrombocytopenia*

DITP refers to acute, immune-mediated thrombocytopenia.  DITP should be suspected when a patient, child or adult, has sudden, severe thrombocytopenia.  DITP is even more strongly suspected when a patient has repeated episodes of sudden, severe thrombocytopenia.  This clinical course is not consistent with a diagnosis of ITP.  Drugs and other substances that cause thrombocytopenia by marrow suppression are included in these databases.  All substances that can cause immune-mediated thrombocytopenia are now included together with approved drugs in the databases of single and group patient reports.  These include foods, beverages, herbal remedies, and other substances.

These data are derived from the systematic reviews listed first in the publication list. Systematic reviews of all published case reports describing drug-induced thrombocytopenia are conducted every two years to update these databases. Our next update will be 2016.

Database of results of tests for drug-dependent, platelet-reactive antibodies in patients with suspected DITP.  The data are from the Platelet and Neutrophil Immunology Laboratory of the BloodCenter of Wisconsin, Milwaukee, WI, collected from 1995 through December 31, 2010.  These data are derived from Reese JA, Li X, Hauben M, Aster RH, Bougie DW, Curtis BR, George JN, Vesely SK. Blood 116 (12): 2127-2133, 2010. Supplemental Table


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