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Jun 2018

Grand Rounds and Seminars

Graduate Student Seminar
4/4/2013 12:00 PM - 1:00 PM

Title: "Vitamin D Deficiency and Cardio-Metabolic Risk in a North Indian Community with Highly Prevalent Type 2 Diabetes."

Presenter: Graduate student Tim Braun, Department of Pharmaceutical Sciences, OU College of Pharmacy

CPB 101 (OKC) and 2H37 (Tulsa)

Abstract: Vitamin D deficiency has been implicated in a variety of adverse health outcomes including skeletal and non-skeletal age-related illnesses and cardiovascular risk factors such as type 2 diabetes (T2D), obesity and blood pressure. The purpose of this investigation was to examine serum vitamin D status in a population of Punjabi ancestry from Northern India with a high prevalence of type 2 diabetes (T2D) and evaluate the effects of 25(OH)D levels on cardio-metabolic traits.  A total of 75.8% of participants were classified as vitamin D deficient (<50nmol/L) and only 24.2% of individuals had sufficient (>50nmol/L) 25(OH)D levels. Of particular note was the increased prevalence of vitamin D deficiency in T2D, obese and hypertensive participants. Multiple regression analysis revealed T2D participants had significantly decreased serum 25(OH)D levels. Individuals with low serum 25(OH)D had significantly elevated fasting glucose, BMI and systolic blood pressure.  Interestingly, non-medicated, normoglycemic and non-hypertensive controls exhibited similar trends. These results suggest vitamin D deficiency may increase susceptibility to T2D and therefore provide rationale for investigating preventive measures, such as improving vitamin D intake, as part of an overall strategy to improve glycemic outcomes in the Punjabi community.<o:p _rdeditor_exists="1"> </o:p>
Number of CE Credits: 0