Resident level quizzes are in crimson, student level quizzes are in blue.
Quiz Set: K-001
Kar-Ming Fung, M.D., Ph.D.
1. Extramedullary hematopoiesis (EMH) is a major differential diagnosis of myelolipoma. Which of the following is not true about EMH? Answer
A. EMH is typically multiple rather than solitary. Myelolipoma is often solitary.
B. EMH is usually secondary to severe anemia and various myeloproliferative disorder.
C. EMH often form a mass and the adrenal gland is often involved.
D. EMH is associated with splenomegaly and hepatomegaly.
E. EMH is often associated with skeletal disorders.
2. A 60 year-old pale appearing woman presented with the chief complain of malice, lost of appetitie, fever and petechiae. Physical examination revealed a bluish subcutaneous swelling on her inner thigh. A biopsy was performed and revealed immature atypical cells infiltrating and admixed with the adipocytes. No erythoid cells or megakaryocytes are noted. The atypical cells contain Auer rods and CD34 positive granules and negative for CD20, Pax5 and pancytokeratin. Which of the following is the most likely diagnosis? Answer
A. Myeloid sarcoma.
B. Non-Hodgkins B-cell lymphoma.
C. Dedifferentiated liposarcoma.
D. Extrramedullary hematopoiesis.
E. Undifferentiated high grade sarcoma.
3. Which of the following cells can be mistaken as giant cells or neoplastic giant cells in myelolipoma? Answer
A. Myeloid cells.
B. Erythroid precursor cells.
C. Megakaryocytes.
D. Lymphocytes.
E. Neutrophils.
4. The nature of myelolipoma is most consistent with which of the following? Answer
A. A true neuoplasm with both the adipocytes and hematopoietic components coming from the same clonal origin.
B. A hamartoma.
C. Extrmedullary hematopoiesis in adipose tissue arising in adrenal gland.
D. Dedifferentiated adrenal cortical cell is the origin of these tumors.
Last updated: October, 20, 2014. Contributed by Kar-Ming Fung, M.D., Ph.D.
Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.