Answer and Discussion of Quiz Set: K-004

3.    Which of the following is not true a feature of chromophobe renal cell carcinoma? Answer

A.  Diffuse cytoplasmic positivity for Hale colloidal iron stain

B.  Positive for Pax2

C.  Myxoid or hyalinized stroma

D.  It has three variants- the classic, the mixed, and the eosinophilic

E.  Distinct cellular border

Answer and Discussion: The answer is (C) Chromophobe renal cell carcinoma can have eosinophilic changes. When the eosinophilic changes exceed 80% of the tumor cells, it it would qualify the tumor to be the eosinophilic variant of chromophobe renal cell carcinoma. It is the only renal cell carcinoma that has diffuse cytoplasmic Hale colloidal iron staining. Myxoid or hyalinized stroma is not a feature of chromophobe renal cell carcinoma. .