Resident level quizzes are in crimson, student level quizzes are in blue.

Quiz Set: N-007

Kar-Ming Fung, M.D., Ph.D.

1.    Which of the molecular testing can be used to distinguish chondrosarcoma from chordoid meningioma?   Answer

A.  BRAF V600E mutation

B.  Isochromosome 17

C.  Deletion of chromosome 1p and 19q

D.  Mutation of isocitrate dehydrogenase 1 and 2 gene (IDH1, IDH2)

E. Mutation or deletion of SMARCB1/INI1

2.    Which of the following tumors is a WHO grade I tumor?   Answer

A. Chordoid meningioma

B.  Papillary meningioma

C.  Clear cell meningioma

D.  Rhabdoid meningioma

E.  Secretory meningioma

3.    A well-circumscribed non-infiltrating tumor near the foramen of Monro, as evaluated by MRI, was resected from a 48 year-old woman. Histologically, the tumor has a mucoid stroma populated by nests and cords of peithelioid cells. Prominent lymphoplasmacytic infiltrates are also present. In some areas, the tumor is rimmed by areas with non-tumoral piloid gliosis which reflects the well-circumscribed nature as assessed by MRI. There is no mitotic figure present. The tumor cells are positive for glial fibrillary acidic protein (GFAP) and CD34, negtative for synaptophysin, cytokeratin, epithelial membrane antigen (EMA), CD18, or brachyury. Which of the following is the correct diagnosis?   Answer

A.  Chordoid meningioma, WHO grade II

B.  Chordoid glioma, WHO grade II

C.  Clear cell ependymoma

D.  Chordoma

E.  Central neurocytoma with mucoid changes

4.    Which of the following tumor is likely to be assocated with significant lymphoplasmacytic infiltration and occasionally with hematological manifestations including Castleman syndrome?   Answer

A.  Chordoid meningioma, WHO grade II

B.  Chordoid glioma, WHO grade II

C.  Clear cell meningioma, WHO grade II

D.  Germinoma

E.  Secretory meningioma, WHO grade I

Last updated: December 1, 2014. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.