Resident level quizzes are in crimson, student level quizzes are in blue.

Quiz Set: N-024

Kar-Ming Fung, M.D., Ph.D.

1.    What is the histologic grade of diffuse astrocytoma in the WHO classification system?   Answer

A.  I

B.  II

C.  III

D.  IV

E.  V

2.    Which of the following morphologic features is sufficient to make a diagnosis of glioblastoma when the other features are compatible with such a diagnosis?  Answer

A.  Increased mitosis

B.  Endothelial proliferation

C.  Patchy distribution of positive immunoreactivity for glial fibrillary acidic protein (GFAP)

D.  Increased nulcear pleomorphism

E.  Presence of sarcomatous component that is non-immunoreactive to glial fibrillary acidic protein (GFAP)

3.    Which of the following features is true about glioblastomas?  Answer

A.  Secondary glioblastomas develop in older patients compared to primary glioblastoma

B.  T53 mutation is uncommon

C.  Giant cell glioblastoma carries a worse prognosis

D.  The 5 years survival rate for glioblastoma patient of all ages is about 20%

E.  Epidermal growth factor receptor (EGFR) amplication is common in older patients

Last updated: October, 20. 2011. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.