Clinical information:  A 56 year-old African American woman presented with constitutional symptoms of vague abdominal pain, fatigue and weight loss. Her past medical history was significant for hypertension and otherwise unremarkable. Physical examination was remarkable for abdominal fullness and hepatosplenomegaly. A chest and abdominal computed tomography scan showed normal pulmonary and mediastinal anatomy with a moderately enlarged liver and spleen. Her laboratory data, including routine chemistries and complete blood count, were within normal limits, albeit a borderline low platelet count. Liver function tests were normal. Anti-mitochondrial antibody (AMA), antinuclear antibody (ANA), antineutrophil cytoplasmic antibodies (ANCA) and anti-smooth muscle antibody were all negative. Hepatitis and CMV serologies were also negative. A liver biopsy was performed.

A	B	C	D	E Reticulin	F Trichrome
G	H CK7	I CK7	Scanned slide	Scanned slide Trichrome

What is your diagnosis