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There is growing evidence suggesting that the evolutionarily conserved insulin-like growth factor-1 (IGF-1) signaling pathway regulates both life span and development of age-related diseases, including cancer.
There is strong clinical and experimental evidence demonstrating that diet-induced obesity promotes the development of vascular cognitive impairment (VCI), which develops as a result of decreased cerebral blood flow due to structural and functional alterations of the cerebral microcirculation.