ROCA - Reynolds Oklahoma Center on Aging

GREATER ENDOTHELIAL APOPTOSIS AND OXIDATIVE STRESS IN PATIENTS WITH PERIPHERAL ARTERY DISEASE.

CALORIC RESTRICTION CONFERS ANTIOXIDATIVE, PROANGIOGENIC AND ANTIINFLAMMATORY EFFECTS PRESERVING A YOUTHFUL PHENOTYPE IN CEREBROMICROVASCULAR ENDOTHELIAL CELLS.

AGING EXACERBATES OBESITY-INDUCED CEREBROMICROVASCULAR RAREFACTION, NEUROVASCULAR UNCOUPLING, AND COGNITIVE DECLINE IN MICE.

HIPPOCAMPAL SUBREGIONS EXHIBIT BOTH DISTINCT AND SHARED TRANSCRIPTOMIC RESPONSES TO AGING AND NONNEURODEGENERATIVE COGNITIVE DECLINE.

EFFECTS OF WHOLE BRAIN RADIATION ON MICROVASCULATURE AND COGNITION

Whole brain irradiation (WBI) therapy leads to progressive problems with learning and memory in approximately 20-50% of individuals treated for metastatic brain cancer. Our overall goal is to develop therapeutic interventions that decrease the effects of radiation-induced impairments in learning and memory.

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Ongoing Studies

GREATER ENDOTHELIAL APOPTOSIS AND OXIDATIVE STRESS IN PATIENTS WITH PERIPHERAL ARTERY DISEASE.

CALORIC RESTRICTION CONFERS ANTIOXIDATIVE, PROANGIOGENIC AND ANTIINFLAMMATORY EFFECTS PRESERVING A YOUTHFUL PHENOTYPE IN CEREBROMICROVASCULAR ENDOTHELIAL CELLS.

AGING EXACERBATES OBESITY-INDUCED CEREBROMICROVASCULAR RAREFACTION, NEUROVASCULAR UNCOUPLING, AND COGNITIVE DECLINE IN MICE.

HIPPOCAMPAL SUBREGIONS EXHIBIT BOTH DISTINCT AND SHARED TRANSCRIPTOMIC RESPONSES TO AGING AND NONNEURODEGENERATIVE COGNITIVE DECLINE.

EFFECTS OF WHOLE BRAIN RADIATION ON MICROVASCULATURE AND COGNITION

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Sister Organizations

Oklahoma Healthy Aging Initiative

Donald W. Reynolds Department of Geriatric Medicine

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