Publication

There is strong clinical and experimental evidence demonstrating that diet-induced obesity promotes the development of vascular cognitive impairment (VCI), which develops as a result of decreased cerebral blood flow due to structural and functional alterations of the cerebral microcirculation.

Publication

Over the past three decades, dietary restriction (DR) has become the "gold standard" against which manipulations that retard aging are compared. Because DR has been shown to increase the lifespan of a wide variety of organisms ranging from invertebrates to rodents, DR is viewed as a universal aging intervention. However, a recent study suggests that the genotype of an animal is a major determinant in the ability of the animal to respond to DR.