Publication

There is strong clinical and experimental evidence demonstrating that diet-induced obesity promotes the development of vascular cognitive impairment (VCI), which develops as a result of decreased cerebral blood flow due to structural and functional alterations of the cerebral microcirculation.

Publication

One of the most widely accepted theories in aging research is the free radical or oxidative stress theory of aging, which argues that the age-related loss of physiological function and age-related increase in pathology are due to the progressive accumulation of oxidative damage. Although this theory is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level, most of the evidence in support of this theory is correlative. 

Publication

Over the past three decades, dietary restriction (DR) has become the "gold standard" against which manipulations that retard aging are compared. Because DR has been shown to increase the lifespan of a wide variety of organisms ranging from invertebrates to rodents, DR is viewed as a universal aging intervention. However, a recent study suggests that the genotype of an animal is a major determinant in the ability of the animal to respond to DR.

Publication

The Summer Training Courses in Experimental Aging Research will be held in June from 2013 through 2017. The five-day Course will be directed by Dr. Richardson and the course site will rotate among three host institutions: the University of Washington at Seattle, WA, Oklahoma University Health Sciences Center at Oklahoma City, OK, and the Buck Institute for Age Research at Novato, CA.

Publication

Whole brain irradiation (WBI) therapy leads to progressive problems with learning and memory in approximately 20-50% of individuals treated for metastatic brain cancer. Our overall goal is to develop therapeutic interventions that decrease the effects of radiation-induced impairments in learning and memory.

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