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Quiz Set: K-004

Kar-Ming Fung, M.D., Ph.D.

1.    Which of the following is not true regarding chromophobe renal cell carcinoma? Answer

A.  Most cases are diagnosed at stage 1 or 2 and have good prognosis

B.  Fuhrman or ISUP grading should not be applied as histologic grade is not a good prognostic indicator

C.  Metastasis is rare in chromophobe renal cell carcinoma and involve only 6% of cases

D.  In order to qualify for a diagnosis of the eosinophilic variant of chromophobe carcinoma, at least 80% of the cells have to be oncocytic

E.  Chromophobe renal cell carcinoma arises from the intercalated cells of the cortical collecting duct.

2.   Which of the followings can be used to differentiate eosinophilic variant of chromophobe renal cell carcinoma from other eosinophilic renal cell carcinomas? Answer

A.  Vimentin (+), C-kit (-), E-cadherin (-), AMACR (-), TFE3 (-)

B.  Vimentin (-), C-kit (+), E-cadherin (+), AMACR (-), TFE3 (+)

C.  Vimentin (+), C-kit (+/-), E-cadherin (+/-), AMACR (+), TFE3 (-)

D.  Vimentin (-), C-kit (+), E-cadherin (+), AMACR (-), TFE3 (-)

3.    Which of the following is not true a feature of chromophobe renal cell carcinoma? Answer

A.  Diffuse cytoplasmic positivity for Hale colloidal iron stain

B.  Positive for Pax2

C.  Myxoid or hyalinized stroma

D.  It has three variants- the classic, the mixed, and the eosinophilic

E.  Distinct cellular border

Last updated: April 7, 2017. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.